Aging of platelets stored for transfusion

被引：13
|
作者：
Smethurst, Peter A. [1 ,2 ]
机构：
[1] NHS Blood & Transplant, Components Dev Lab, Cambridge, England
[2] Univ Cambridge, Dept Haematol, Cambridge CB2 0PT, England
来源：
PLATELETS | 2016年 / 27卷 / 06期
关键词：
Storage; aging; transfusion; IN-VIVO RECOVERY; PATHOGEN INACTIVATION; EXTENDED STORAGE; APHERESIS PLATELETS; ADDITIVE SOLUTION; CRYOPRESERVED PLATELETS; THROMBUS FORMATION; COUNT INCREMENTS; AMOTOSALEN-HCL; P-SELECTIN;
D O I：
10.3109/09537104.2016.1171303
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
A goal of platelet storage is to maintain the quality of platelets from the point of donation to the point of transfusion - to suspend the aging process. This effort is judged by clinical and laboratory measures with varying degrees of success. Recent work gives encouragement that platelets can be maintained ex vivo beyond the current 5 -7 day shelf life whilst maintaining their quality, as measured by posttransfusion recovery and survival. However, additional measures are needed to validate the development of technologies that may further reduce the aging of stored platelets, or enhance their hemostatic properties.
引用
收藏
页码：526 / 534
页数：9
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