A Comparative Study of Antioxidant System and Intensity of Lipid Peroxidation in Type 2 Diabetes Mellitus and Ischemic Stroke Aggravated and Not Aggravated by Type 2 Diabetes Mellitus

被引：0
|
作者：
Tsakanova, G. V. [1 ]
Ayvazyan, V. A. [1 ]
Boyajyan, A. S. [1 ]
Arakelova, E. A. [1 ]
Grigoryan, G. S. [2 ]
Guevorkyan, A. A. [3 ]
Mamikonyan, A. A. [3 ]
机构：
[1] Natt Acad Sci Republ Armenia, Inst Mol Biol, Yerevan, Armenia
[2] St Gregory Illuminator Sci Med Ctr, Yerevan, Armenia
[3] Minist Hlth Republ Armenia, Armenia Med Ctr, Yerevan, Armenia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2011年 / 151卷 / 05期
关键词：
ischemic stroke; diabetes; antioxidants; lipid hydroperoxides; BLOOD-BRAIN-BARRIER; OXIDATIVE STRESS; FREE-RADICALS; INJURY;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The survey was conducted on patients with type 2 diabetes mellitus and on patients with ischemic stroke aggravated and not aggravated by type 2 diabetes mellitus. A comparative study of the function of antioxidant system and the intensity of oxidative stress induced by lipid peroxidation (LPO) in the blood was carried out. Stroke aggravated by diabetes was characterized by higher intensity of LPO than stroke not aggravated by diabetes, which, apparently, determines the more severe course of stroke in patients with diabetes. The mechanisms of compensatory response to oxidative stress at the level of antioxidants in stroke aggravated by diabetes also differed from those in stroke not aggravated by diabetes. These data indicate the need of using water-soluble low-molecular-weight antioxidants in the treatment of stroke aggravated by diabetes.
引用
收藏
页码：564 / 566
页数：3
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