Interaction of 1,4-Dihydroxy-9,10-Anthraquinone with Calf Thymus DNA: A Comparison with Anthracycline Anticancer Drugs

被引：27

作者：

Guin, Partha Sarathi ^{[1
,2
]}

Das, Saurabh ^{[2
]}

Mandal, Parikshit Chandra ^{[1
]}

机构：

[1] Saha Inst Nucl Phys, Div Chem Sci, Kolkata 700064, India

[2] Jadavpur Univ, Dept Chem, Kolkata 700032, India

来源：

JOURNAL OF SOLUTION CHEMISTRY | 2011年 / 40卷 / 03期

关键词：

QH(2); Calf thymus DNA; UV-Visible spectroscopy; Fluorescence; Binding constant; Binding site size; CHROMOMYCIN A(3); ADRIAMYCIN; ANTIBIOTICS; COMPLEXES; BINDING; CARDIOTOXICITY; INTERCALATION; DAUNORUBICIN; MITHRAMYCIN;

D O I：

10.1007/s10953-011-9654-x

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The anthracycline drugs adriamycin and daunorubicin, efficient in the treatment of various human cancers, form strong intercalation complexes with DNA. The therapeutic efficacy and toxicity of such anticancer drugs are governed by biochemical reactions of the core dihydroxy-9,10-anthraquinone unit. The high cost and toxic side effects of anthracycline drugs limit their use in cancer therapy. For a few decades, efforts have been made to find cheap, less toxic yet efficient analogues of anthracyclines. This work on 1,4-dihydroxy-9,10-anthraquinone (QH(2)), a simple analogue of the anthracyclines, was carried out to compare its biochemical properties with anthracyclines. UV-Vis and fluorescence spectroscopic methods were used to analyze interaction of the compound with calf thymus DNA. The data were used to evaluate the binding constant and site size.

引用

页码：492 / 501

页数：10

共 50 条

[21] Characterization of 1,4-/1,8-dihydroxy-9,10-anthraquinone films
Mahajan, A
Singh, A
Kumar, R
Bedi, RK
Pramila
Kumar, S
THIN SOLID FILMS, 2001, 385 (1-2) : 36 - 42
[22] MAGNETIC EXCHANGE INTERACTIONS IN BINUCLEAR TRANSITION-METAL COMPLEXES .18. DIANIONS OF 5,8-DIHYDROXY-1,4-NAPHTHOQUINONE, 1,4-DIHYDROXY-9,10-ANTHRAQUINONE, AND 1,5-DIHYDROXY-9,10-ANTHRAQUINONE AS BRIDGING LIGANDS IN COPPER(II) AND NICKEL(II) COMPLEXES
PIERPONT, CG
FRANCESCONI, LC
HENDRICKSON, DN
INORGANIC CHEMISTRY, 1978, 17 (12) : 3470 - 3477
[23] Synthesis and Antitumor Activity of 2-[1-(2-Formylamido-3-phenylpropionyloxy)alkyl]-1,4-dihydroxy-9,10-anthraquinone Derivatives
Jin Li-li
Jin Guang-zhu
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 2012, 28 (06) : 971 - 975
[24] Synthesis of 2-{1-[(4-Formamidophenyl)acetoxy]alkyl}-1,4-dihydroxy-9,10-anthraquinone and Evaluation of Its Antitumor Activity
Piao, Guangchun
Quan, Zheshan
Jin, Guangzhu
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2009, 29 (04) : 564 - 568
[25] Sodium 1, 4-dihydroxy-9, 10-anthraquinone-2-sulphonate interacts with calf thymus DNA in a way that mimics anthracycline antibiotics: an electrochemical and spectroscopic study
Guin, Partha Sarathi
Das, Saurabh
Mandal, P. C.
JOURNAL OF PHYSICAL ORGANIC CHEMISTRY, 2010, 23 (06) : 477 - 482
[26] Optical absorption studies on 1,4-/1,8-dihydroxy-9,10-anthraquinone films
Mahajan, A
Singh, A
Kumar, R
Bedi, RK
Kumar, S
INDIAN JOURNAL OF ENGINEERING AND MATERIALS SCIENCES, 2000, 7 (5-6) : 399 - 403
[27] Radiation-induced double-strand modification in calf thymus DNA in the presence of 1,2-dihydroxy-9,10-anthraquinone and its Cu(II) complex
Das, S
Saha, A
Mandal, PC
ENVIRONMENTAL HEALTH PERSPECTIVES, 1997, 105 : 1459 - 1462
[28] The Binding of a Hydroxy-9,10-anthraquinone CuII Complex to Calf Thymus DNA: Electrochemistry and UV/Vis Spectroscopy
Guin, Partha S.
Mandal, Parikshit C.
Das, Saurabh
CHEMPLUSCHEM, 2012, 77 (05): : 361 - 369
[29] Luminescent Study of the Binding Interaction on 1,4-Dihydroxy-2,3-Dimethyl-9,10-Anthraquinone with Titanium Dioxide Nanoparticles
S. Pushpam
D. Yamini
V. Ramakrishnan
Journal of Applied Spectroscopy, 2014, 81 : 371 - 376
[30] Luminescent Study of the Binding Interaction on 1,4-Dihydroxy-2,3-Dimethyl-9,10-Anthraquinone with Titanium Dioxide Nanoparticles
Pushpam, S.
Yamini, D.
Ramakrishnan, V.
JOURNAL OF APPLIED SPECTROSCOPY, 2014, 81 (03) : 371 - 376

← 1 2 3 4 5 →