Non-Competitive NMDA Receptor Antagonist Hemantane Reduces Ethanol Consumption in Long-Term Alcohol Experienced Rats

被引：3
|
作者：
Kolik, L. G. [1 ]
Nadorova, A. V. [1 ]
Seredenin, S. B. [1 ]
机构：
[1] VV Zakusov Res Inst Pharmacol, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2017年 / 164卷 / 02期
关键词：
hemantane; ethanol; behavioral sensitization; ethanol consumption; alcohol-deprivation effect; NEUROTROPHIC FACTOR; MEMANTINE; MICE; HYPERLOCOMOTION; SENSITIZATION; HIMANTANE;
D O I：
10.1007/s10517-017-3946-0
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Activity of hemantane, an amino adamantane derivative, exhibiting the properties of lowaffinity non-competitive NMDA receptor antagonist, was evaluated in experimental in vivo models of alcoholism. Hemantane had no effects on the formation and manifestation of behavioral sensitization to ethanol in DBA/2 mice. Under conditions of free choice between 10% ethanol and water, hemantane (20 mg/kg/day for 14 days, intraperitoneally) significantly reduced the daily ethanol intake in random-bred male rats with formed alcohol motivation (> 4 g/kg of ethanol). During modelling of withdrawal syndrome, hemantane administered intraperitoneally in doses of 5-20 mg/kg dose-dependently attenuated alcohol-deprivation effect after acute withdrawal with no effects on protracted abstinence. It was found that hemantane suppressed alcohol drinking behavior in long-term ethanol experienced rats and attenuated alcohol-seeking behavior after acute withdrawal.
引用
收藏
页码：152 / 157
页数：6
相关论文
共 50 条
  • [21] NMDA receptor antagonist MK-801 abolishes phrenic long-term facilitation in rats
    Zhang, Y
    McGuire, M
    White, DP
    Ling, LM
    FASEB JOURNAL, 2002, 16 (04): : A69 - A69
  • [22] The synergistic effect of fluoxetine on the locomotor hyperactivity induced by MK-801, a non-competitive NMDA receptor antagonist
    Maj, J
    Rogoz, Z
    Skuza, G
    Wedzony, K
    JOURNAL OF NEURAL TRANSMISSION, 1996, 103 (1-2) : 131 - 146
  • [23] VARENICLINE REDUCES ETHANOL CONSUMPTION IN HEAVY LONG-TERM DRINKING RATS AND REDUCES STRESS BUT NOT CUE-INDUCED RELAPSE OF ETHANOL SEEKING
    Simms, J. A.
    Holgate, J. Y.
    Steensland, P.
    Bartlett, S. E.
    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2009, 33 (06) : 304A - 304A
  • [24] Long-term ethanol intoxication reduces inflammatory responses in rats
    Carvalho, EM
    Briton, GAC
    Pessoa, BBGP
    Ribeiro, RA
    Capaz, FR
    BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 2005, 38 (01) : 81 - 89
  • [25] Novel uncompetitive N-methyl-D-aspartate (NMDA)-receptor antagonist MRZ2/579 suppresses ethanol intake in long-term ethanol-experienced rats and generalizes to ethanol cue in drug discrimination procedure
    Hölter, SM
    Danysz, W
    Spanagel, R
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2000, 292 (02): : 545 - 552
  • [26] Some behavioural and electrophysiological alterations in rats treated acutely and subchronically by MK-801, a non-competitive NMDA antagonist
    Szabo, A.
    Lukacs, A.
    Nagymajtenyi, L.
    TOXICOLOGY LETTERS, 2005, 158 : S58 - S59
  • [27] Macaque brain PET study on [11C]ASP0777, an non-competitive NMDA receptor antagonist
    Noda, Akihiro
    Murakami, Yoshihiro
    Miyoshi, Sosuke
    Nishimura, Shintaro
    JOURNAL OF NUCLEAR MEDICINE, 2014, 55
  • [28] Effects of competitive and non-competitive NMDA receptor antagonists on behavioral responses induced by 7-OH-DPAT and quinpirole in rats
    DallOlio, R
    Rimondini, R
    Gandolfi, O
    PHARMACOLOGICAL RESEARCH, 1997, 36 (03) : 203 - 209
  • [29] THE EFFECT OF NON-COMPETITIVE NMDA RECEPTOR ANTAGONIST MK801 ON HIPPOCAMPUS-PREFRONTAL CORTEX SYNAPTIC RESPONSES AND EXECUTIVE COGNITIVE FUNCTION IN RATS
    Blot, Kevin
    Kimura, Shin-Ichi
    Kemp, Anne
    Manahan-Vaughan, Denise
    Giros, Bruno
    Otani, Satoru
    SCHIZOPHRENIA RESEARCH, 2010, 117 (2-3) : 393 - 393
  • [30] Long-term potentiation in the presence of NMDA receptor antagonist arylalkylamine spider toxins
    Albensi, BC
    Alasti, N
    Mueller, AL
    JOURNAL OF NEUROSCIENCE RESEARCH, 2000, 62 (02) : 177 - 185
12345