The cytotoxicity of Saponins correlates with their cellular internalization

被引：16
|
作者：
Wang, Yibing
Zhang, Yichun
Yu, Biao
机构：
[1] State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032
来源：
CHEMMEDCHEM | 2007年 / 2卷 / 03期
关键词：
Cellular internalization; Cytotoxicity; Fluorescent probes; Lysosomes; Spirostan saponin;
D O I：
10.1002/cmdc.200600235
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Saponins however, do not anchor themselves to are a broad class of plant-derived compounds the cell membrane, but are instead compounds that are commonly used as a internalized. They localize specifically to tool to disrupt cell membranes. Some acidic organelles such as lysosomes, and saponins such as that shown above,
引用
收藏
页码：288 / +
页数：5
相关论文
共 50 条
  • [21] Synthesis and Cytotoxicity of Bidesmosidic Betulin and Betulinic Acid Saponins
    Gauthier, Charles
    Legault, Jean
    Lavoie, Serge
    Rondeau, Simon
    Tremblay, Samuel
    Pichette, Andre
    JOURNAL OF NATURAL PRODUCTS, 2009, 72 (01): : 72 - 81
  • [22] Light-Controlled Cellular Internalization and Cytotoxicity of Nucleic Acid-Binding Agents: Studies in Vitro and in Zebrafish Embryos
    Penas, Cristina
    Sanchez, Mateo I.
    Guerra-Varela, Jorge
    Sanchez, Laura
    Eugenio Vazquez, M.
    Mascarenas, Jose L.
    CHEMBIOCHEM, 2016, 17 (01) : 37 - 41
  • [23] New pregnane saponins from Ecdysanthera rosea and their cytotoxicity
    Zhu, Xiangdong
    Wu, Guisheng
    Xiang, Jianying
    Luo, Huairong
    Luo, Shide
    Zhu, Hongmei
    Wang, Yifen
    FITOTERAPIA, 2011, 82 (04) : 632 - 636
  • [24] A polymeric domain that promotes cellular internalization
    Kolonko, Erin M.
    Kiessling, Laura L.
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (17) : 5626 - +
  • [25] A polymeric domain that promotes cellular internalization
    Kolonko, Erin M.
    Kiessling, Laura L.
    Journal of the American Chemical Society, 2008, 130 (17): : 5626 - 5627
  • [26] Cellular internalization and targeting of nanoparticles.
    Rozenzhak, SM
    Caserta, TM
    Stone, MO
    Naik, RR
    Kadakia, MP
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 229 : U1150 - U1151
  • [27] A pair of isomeric saponins with cytotoxicity from Albizzia julibrissin
    Zou, K
    Cui, JR
    Wang, B
    Zhao, YY
    Zhang, RY
    JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2005, 7 (06) : 783 - 789
  • [28] Determination of cellular internalization of fluoresceinated oligonucleotides
    Benimetskaya, L
    Tonkinson, J
    Stein, CA
    ANTISENSE TECHNOLOGY, PT A, 2000, 313 : 287 - 297
  • [29] In vitro studies on cytotoxicity, internalization and genotoxicity of graphene oxide
    Dominguez, O. C.
    Ballester, S. S.
    Beneyto, M. J.
    Fernandez, A. M. C.
    Gallego, A. J.
    TOXICOLOGY LETTERS, 2021, 350 : S102 - S103
  • [30] Cytotoxicity and Internalization of Polymer Hydrogel Capsules by Mammalian Cells
    Zelikin, Alexander N.
    Breheney, Kerry
    Robert, Remy
    Tjipto, Elvira
    Wark, Kim
    BIOMACROMOLECULES, 2010, 11 (08) : 2123 - 2129
12345