Individual differences in threat sensitivity predict serotonergic modulation of amygdala response to fearful faces

被引:121
|
作者
Cools, R
Calder, AJ
Lawrence, AD
Clark, L
Bullmore, ET
Robbins, TW
机构
[1] Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA
[2] Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England
[3] MRC, Cognit & Brain Sci Unit, Cambridge, England
[4] Addenbrookes Hosp, Dept Psychiat, Brain Mapping Unit, Cambridge, England
基金
英国医学研究理事会;
关键词
serotonin depletion; fear; functional imaging; amygdala; hippocampus; faces;
D O I
10.1007/s00213-005-2215-5
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Rationale: In this study we used functional magnetic resonance imaging (fMRI) to examine the effects of acute tryptophan depletion (ATD), a well-recognised method for inducing transient cerebral serotonin depletion, on brain activation to fearful faces. Objectives: We predicted that ATD would increase the responsiveness of the amygdala to fearful faces as a function of individual variation in threat sensitivity. Methods: Twelve healthy male volunteers received a tryptophan depleting drink or a tryptophan balancing amino acid drink (placebo) in a double-blind crossover design. Five hours after drink ingestion participants were scanned whilst viewing fearful, happy and neutral faces. Results: Consistent with previous findings, fearful faces induced significant signal change in the bilateral amygdala/hippocampus as well as the fusiform face area and the right dorsolateral prefrontal cortex. Furthermore, ATD modulated amygdala/hippocampus activation in response to fearful relative to happy faces as a function of self-reported threat sensitivity (as measured with the Behavioral Inhibition Scale; Carver CS, White TL (1994) Behavioral inhibition, behavioral activation, and affective responses to impending reward and punishment: the BIS/BAS scales. J Pers Soc Psychol 67:319-333). Conclusion: The data support the hypothesis that individual variation in threat sensitivity interacts with manipulation of 5-HT function to bias the processing of amygdala-dependent threat-relevant stimuli.
引用
收藏
页码:670 / 679
页数:10
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