Synthesis of phthalimido/succinimido [2-substituted aryl-3-(N7-theophyllinylacetamidyl)-4-oxo-1,3-thiazolidin-5-yl] ethanoic acids

被引：0
|
作者：
Sharma, R [1 ]
Ahmed, M [1 ]
Talesara, GL [1 ]
机构：
[1] Mohan Lal Sukhadia Univ, Synth Organ Chem Lab, Dept Chem, Udaipur 313001, India
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2005年 / 15卷 / 01期
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D O I：
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中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Reaction of ethyl NI-theophyllinyl acetate 1 with hydrazine hydrate gives N(7-)theophyllinylacetyl hydrazine 2, which on condensation with various aromatic aldehydes afford corresponding arylidene derivatives 3(a-h). A series of 2-substituted aryl-3-(N-7 -theophyllinylacetamidyl)-4-oxo-1,3-thiazolidin-5-yl ethanoic acids (4a-h) have been synthesized via cycloaddition of (3a-h) with mercaptosuccinic acid. Compounds (4a-h) have also been converted into corresponding ethanoyl chloride derivatives (5a-h) and condensed with N-hydroxyphthalimide and N-hydroxysuccinimide to furnish titled compounds (6a-p).
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页码：35 / 38
页数：4
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