Use of Potentially Inappropriate Medications in People With Dementia in Vietnam and Its Associated Factors

被引：12

作者：

Tuan Anh Nguyen ^{[1
]}

Thang Pham ^{[2
]}

Huyen Thi Thanh Vu ^{[2
]}

Thanh Xuan Nguyen ^{[2
]}

Trinh Thi Vu ^{[2
]}

Binh Thi Thanh Nguyen ^{[2
]}

Ngoc Quynh Nguyen ^{[2
]}

Binh Thanh Nguyen ^{[2
]}

Tam Ngoc Nguyen ^{[2
]}

Sinh Viet Phan ^{[2
]}

Anh Trung Nguyen ^{[2
]}

Tuan Le Pham ^{[3
,4
]}

Ha Thu Dang ^{[1
]}

Kalisch-Ellett, Lisa ^{[1
]}

Gillam, Marianne ^{[1
]}

Pratt, Nicole ^{[1
]}

Qiang, Sun ^{[5
]}

Wang, Haipeng ^{[5
]}

Kanjanarach, Tipaporn ^{[6
]}

Hassali, Mohamed Azmi Ahmad ^{[7
]}

Babar, Zaheer-Ud-Din ^{[8
]}

Ab Razak, Asrenee ^{[9
]}

Chinwong, Dujrudee ^{[10
]}

Roughead, Elizabeth E. ^{[1
]}

机构：

[1] Univ South Australia, Sch Pharm & Med Sci, Qual Use Med & Pharm Res Ctr, Sansom Inst Hlth Res, Reid Bldg,Frome Rd, Adelaide, SA 5001, Australia

[2] Natl Geriatr Hosp Vietnam, Hanoi, Vietnam

[3] Hanoi Med Univ, Hanoi, Vietnam

[4] Minist Hlth Vietnam, Hanoi, Vietnam

[5] Shandong Univ, Sch Hlth Care Management, Ctr Hlth Management & Policy, Jinan, Shandong, Peoples R China

[6] Khon Kaen Univ, Fac Pharmaceut Sci, Khon Kaen, Thailand

[7] Univ Sains Malaysia, Sch Pharmaceut Sci, George Town, Malaysia

[8] Univ Huddersfield, Dept Pharm, Huddersfield, W Yorkshire, England

[9] Univ Sains Malaysia, Sch Med Sci, Dept Psychiat, George Town, Malaysia

[10] Chiang Mai Univ, Fac Pharm, Dept Pharmaceut Care, Chiang Mai, Thailand

来源：

AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS | 2018年 / 33卷 / 07期

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

dementia; quality use of medicines; potentially inappropriate medicines; anticholinergics; antipsychotics; sedatives; GINKGO-BILOBA EXTRACT; CHOLINESTERASE-INHIBITORS; COGNITIVE IMPAIRMENT; ALZHEIMERS-DISEASE; CONCURRENT USE; OLDER-ADULTS; DRUG-USE; RISK; EFFICACY; ANTICHOLINERGICS;

D O I：

10.1177/1533317518768999

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

This study examined the use of potentially inappropriate medicines that may affect cognition (PIMcog) in people with dementia and its associated factors. Medical records of all outpatients with dementia attending a tertiary hospital in Vietnam between January 1, 2015, and December 31, 2016, were examined. Medicine use was assessed against a list of PIMcog. Variables associated with having a PIMcog were assessed using a multiple logistic regression. Of the 128 patients, 41% used a PIMcog, 39.1% used cholinesterase inhibitors (CEIs) concomitantly with anticholinergics, and 18% used antipsychotics. The number of hospital visits (adjusted odds ratio [OR]: 1.08; 95% confidence interval [CI]: 1.02-1.16) and number of treating specialists (adjusted OR: 0.61; 95% CI: 0.45-0.83) were associated with PIMcog use. This study highlights a high-level use of medicines that can further impair cognition or reduce the effectiveness of CEIs in people with dementia. Efforts to improve quality use of medicines for this population are warranted.

引用

页码：423 / 432

页数：10

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