Placental pathology and outcome after perinatal asphyxia and therapeutic hypothermia

被引：11
|
作者：
Frank, C. M. C. [1 ]
Nikkels, P. G. J. [2 ]
Harteman, J. C. [1 ]
van Haastert, I. C. [1 ]
Benders, M. J. N. L. [1 ]
Koopman-Esseboom, C. [1 ]
de Vries, L. S. [1 ]
Groenendaal, F. [1 ]
机构：
[1] Univ Med Ctr Utrecht, Wilhelmina Childrens Hosp, Dept Neonatol, Room KE 04-123-1,Lundlaan 6, NL-3584 EA Utrecht, Netherlands
[2] Univ Med Ctr Utrecht, Dept Pathol, Utrecht, Netherlands
来源：
JOURNAL OF PERINATOLOGY | 2016年 / 36卷 / 11期
关键词：
PERIVILLOUS FIBRIN DEPOSITION; FETAL THROMBOTIC VASCULOPATHY; NEONATAL ENCEPHALOPATHY; CEREBRAL-PALSY; BRAIN-INJURY; TERM INFANTS; ASSOCIATION; PATTERNS; BIRTH; RISK;
D O I：
10.1038/jp.2016.110
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
OBJECTIVE: To assess the relationship between placental pathology, pattern of brain injury and neurodevelopmental outcome in term infants with perinatal asphyxia receiving therapeutic hypothermia. STUDY DESIGN: Studies were performed in 76 infants. Death or survival with impairments at 18 to 24 months was used as a composite adverse outcome. Multivariable analysis was performed. RESULTS: Among the 75 infants analyzed, the predominant pattern of brain injury was: no injury (n = 27), a white matter/watershed pattern (n = 14), basal-ganglia-thalamic injury (n = 13) or near-total brain injury (n = 21). An adverse outcome was seen in 35 of the 76 infants. Elevated nucleated red blood cells were associated with white matter involvement. Small placental infarcts were more common among infants without brain injury. All other placental abnormalities were not related to both outcome measures. CONCLUSION: In our population of term infants receiving therapeutic hypothermia, no type of placental pathology was related to extensive brain injury or adverse neurodevelopmental outcome.
引用
收藏
页码：977 / 984
页数：8
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