Microwave-assisted solvent-free synthesis of imidazo[1,2-a]pyridines via a three-component reaction

被引：19
|
作者：
Zhang, Huiping [1 ]
Jiang, Lin [1 ]
机构：
[1] Jining Univ, Dept Chem & Chem Engn, Qufu 273155, Shandong, Peoples R China
来源：
TETRAHEDRON LETTERS | 2015年 / 56卷 / 21期
关键词：
Multicomponent reaction; Microwave irradiation; Imidazo[1,2-a]pyridines; Solvent-free; TsOH; H BOND FUNCTIONALIZATION; ONE-POT SYNTHESIS; MULTICOMPONENT REACTION; ORGANIC-SYNTHESIS; CATALYZED ARYLATION; IRIDIUM COMPLEXES; AZOMETHINE YLIDES; C-O; DERIVATIVES; DISCOVERY;
D O I：
10.1016/j.tetlet.2015.04.030
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A facile microwave-assisted three-component reaction of pyridin-2-amine, 3-phenylpropiolaldehyde and alcohol is catalyzed by TsOH under solvent-free conditions to give corresponding imidazo[1,2-a]pyridines in good yields. Reactions proceed with high efficiency and good functional group tolerance. This approach provides a useful protocol for the preparation of functionalized imidazo[1,2-a]pyridine derivatives. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2777 / 2779
页数：3
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