Synthesis and Biological Activity of Amide Compounds Containing Pyrazole Mandelic Acid Groups

被引：6

作者：

Xie, Yan ^{[1
]}

Ruan, Xiang-Hui ^{[1
]}

Gong, Hua-Yu ^{[1
]}

Wang, Yi-Hui ^{[1
]}

Wang, Xiao-Bin ^{[1
]}

Zhang, Ju-Ping ^{[1
]}

Li, Qin ^{[1
]}

Xue, Wei ^{[1
]}

机构：

[1] Guizhou Univ, Key Lab Green Pesticide & Agr Bioengn, State Key Lab Breeding Base Green Pesticide & Agr, Minist Educ,Ctr Res & Dev Fine Chem, Guiyang 550025, Guizhou, Peoples R China

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2017年 / 54卷 / 05期

关键词：

DERIVATIVES;

D O I：

10.1002/jhet.2862

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of novel mandelic acid pyrazole amide compounds were synthesized and characterized. Moreover, their antiviral activities against tobacco mosaic virus were evaluated. The bioassay results indicated that as-prepared compounds showed antiviral activity against tobacco mosaic virus at a concentration of 500g/mL. The curative activity of compound 4g is 59.5%, which was comparable with positive control (Ningnanmycin, 61.0%). The inactivation activity of the compound 4l exhibited 80.1%, which was higher than that of Ningnanmycin (75.0%), and its protective activity was 88.7%, which is comparable with that of Ningnanmycin (90.7%).

引用

页码：2644 / 2649

页数：6

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