Regulation of ion channels by cAMP-dependent protein kinase and A-kinase anchoring proteins

被引：144

作者：

Gray, PC ^{[1
]}

Scott, JD

Catterall, WA

机构：

[1] Univ Washington, Dept Pharmacol, Seattle, WA 98195 USA

[2] Oregon Hlth & Sci Univ, Vollum Inst, Howard Hughes Med Inst, Portland, OR 97201 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 1998年 / 8卷 / 03期

关键词：

D O I：

10.1016/S0959-4388(98)80057-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Subcellular targeting of the cAMP-dependent protein kinase is achieved, in part, through association with A-kinase anchoring proteins (AKAPs). Recent evidence suggests that specific AKAPs direct the kinase to submembrane sites to facilitate phosphorylation and modulation of a variety of ion channels. A new membrane-anchored AKAP targets cAMP-dependent protein kinase to calcium channels and enhances their regulation in multiple cell types.

引用

页码：330 / 334

页数：5

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