Expeditious synthesis of ramipril: An angiotensin converting enzyme (ACE) inhibitor

被引：5
|
作者：
Malakondaiah, Golla China [1 ]
Gurav, V. M. [1 ]
Reddy, Lekkala Amarnath
Babu, Karrothu Srihari
Bhaskar, Bolugoddu Vijaya
Reddy, Padi Pratap
Bhattacharya, Apurba
Anand, Ramasamy Vijaya
机构：
[1] Dr Reddys Labs Ltd, Ctr Excellence, IPDO, Bachupalli 500072, Andhra Pradesh, India
来源：
SYNTHETIC COMMUNICATIONS | 2008年 / 38卷 / 11期
关键词：
boric acid; esterification; L-(+)-mandelic acid; ramipril; resolution;
D O I：
10.1080/00397910801989238
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We document an efficient and cost-effective synthesis of ramipril 1 utilizing (i) an environmentally benign process for the esterification of racemic 2-aza-bicyclo-[3.3.0]-octane-3-carboxylic acid hydrochloride 2 using boric acid as a catalyst and (ii) a robust resolution process for the synthesis of 3a by means of inexpensive and recyclable L-(+)-mandelic acid as key steps.
引用
收藏
页码：1737 / 1744
页数：8
相关论文
共 50 条
  • [21] ACUTE, SUBCHRONIC AND CHRONIC TOXICITY OF THE NEW ANGIOTENSIN CONVERTING ENZYME-INHIBITOR RAMIPRIL
    DONAUBAUER, HH
    MAYER, D
    ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH, 1988, 38-1 (01): : 14 - 20
  • [22] ANGIOTENSIN CONVERTING ENZYME (ACE) IN SCLERODERMA
    CERINIC, MM
    BORSOTTI, M
    BARBIERI, R
    LOMBARDI, A
    LOTTI, T
    MORFINI, M
    SPILLANTINI, G
    PIROLO, F
    CLINICAL RHEUMATOLOGY, 1987, 6 (02) : 300 - 301
  • [23] The angiotensin converting enzyme inhibitor ramipril increases total antioxidant capacity in haemodialysis patients
    Dimitriadis, GD
    Chouliaras, IC
    Economou, ED
    Theodoridis, TG
    Galea, VTH
    Chouliaras, GL
    Metaxatos, GJ
    Cokkinou, VD
    Hadjiconstantinou, VE
    NEPHROLOGY DIALYSIS TRANSPLANTATION, 2005, 20 : V127 - V127
  • [24] Angiotensin converting enzyme inhibitor intoxication: Naloxone to the rescue? Naloxone for ACE inhibitor intoxication
    Robert, Martine
    De Bels, David
    Chaumont, Martin
    Honore, Patrick M.
    Gottignies, Philippe
    AMERICAN JOURNAL OF EMERGENCY MEDICINE, 2019, 37 (06): : 1217.e1 - 1217.e2
  • [25] Amyloid β-protein is degraded by cellular angiotensin-converting enzyme (ACE) and elevated by an ACE inhibitor
    Hemming, ML
    Selkoe, DJ
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (45) : 37644 - 37650
  • [26] CHARACTERIZATION OF ANGIOTENSIN CONVERTING ENZYME (ACE) IN THE TESTIS AND ASSESSMENT OF THE INVIVO EFFECTS OF THE ACE INHIBITOR PERINDOPRIL
    JACKSON, B
    CUBELA, RB
    SAKAGUCHI, K
    JOHNSTON, CI
    ENDOCRINOLOGY, 1988, 123 (01) : 50 - 55
  • [27] RAMIPRIL AND CARDIAC AND RENAL ANGIOTENSIN-CONVERTING ENZYME
    GRIMA, M
    STEPHAN, D
    WELSCH, C
    COQUARD, C
    BARTHELMEBS, M
    IMBS, JL
    ARCHIVES DES MALADIES DU COEUR ET DES VAISSEAUX, 1995, 88 : 43 - 48
  • [28] Angiotensin converting enzyme (ACE) inhibition and angiotensin escape
    Ryan, JW
    FASEB JOURNAL, 2004, 18 (04): : A650 - A650
  • [29] PHARMACOKINETICS OF PENTOPRIL, AN ANGIOTENSIN CONVERTING ENZYME (ACE) INHIBITOR IN RENAL COMPROMISED PATIENTS
    RAKHIT, A
    FELDMAN, G
    TIPNIS, V
    RADENSKY, P
    HURLEY, ME
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 1986, 39 (02) : 221 - 221
  • [30] Antithrombotic effect of captopril, an angiotensin converting enzyme inhibitor (ACE-I)
    Aiello, L
    Iacoviello, L
    Wollny, T
    Donati, MB
    THROMBOSIS AND HAEMOSTASIS, 1997, : P2815 - P2815
12345