New bronchodilators-3:: Synthesis of benzimidazo [1,2-c]-quinazolin-6 (5H)-ones and their thio analogues

被引:0
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作者
Bahekar, RH [1 ]
Rao, ARR [1 ]
机构
[1] Kakatiya Univ, Univ Coll Pharmaceut Sci, Div Med Chem, Warangal 506009, Andhra Pradesh, India
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中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Synthesis of some new benzimidazo [1,2-c] quinazolin-6(5H)-ones (IV) and their thio analogues (III) has been accomplished. The key Intermediates, 2-(2-aminophenyl) benzimidazoles (II) were obtained by direct condensation of substituted anthranilic acids (I) with o-phenylenediamine using polyphosphoric acid (PPA) as dehydrocyclizing agent. Benzimidazo[1,2-c] quinazolin-6(5H)-thiones (III) were obtained by condensing 2-(2-aminophenyl) benzimidazole (II) with carbon disulfide (CS2) and their corresponding oxo analogues IV were synthesized by the oxidation of III, with alkaline KMnO4. The structure of the compounds III and IV have been established on the basis of their elemental analyses and spectral (IR, H-1 NMR and Mass) data. The bronchodilatory activity of compounds IIIa and IVa is reported using in vitro and in vivo animal models.
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页码:225 / 228
页数:4
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