Clinical trials in amyotrophic lateral sclerosis: The tenuous past and the promising future
被引:9
|
作者:
Choudry, RB
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机构:
Massachusetts Gen Hosp, Neurol Clin Trials Unit, Dept Neurol, Boston, MA 02114 USAMassachusetts Gen Hosp, Neurol Clin Trials Unit, Dept Neurol, Boston, MA 02114 USA
Choudry, RB
[1
]
Cudkowicz, ME
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机构:
Massachusetts Gen Hosp, Neurol Clin Trials Unit, Dept Neurol, Boston, MA 02114 USAMassachusetts Gen Hosp, Neurol Clin Trials Unit, Dept Neurol, Boston, MA 02114 USA
Cudkowicz, ME
[1
]
机构:
[1] Massachusetts Gen Hosp, Neurol Clin Trials Unit, Dept Neurol, Boston, MA 02114 USA
amyotrophic lateral sclerosis;
clinical trials;
drug trials;
D O I:
10.1177/0091270005282631
中图分类号:
R9 [药学];
学科分类号:
1007 ;
摘要:
The post decade of research in amyotrophic lateral sclerosis has contributed to a greater understanding of the disease-process, the development of relevant animal models, and the identification of several therapeutic approaches that may delay disease progression. Completed and ongoing clinical trials and the process of selecting drugs for clinical trials are presented.
机构:
Univ Buenos Aires, Sch Med, Dept Physiol & Biophys, Syst Neurosci Sect, Buenos Aires, ArgentinaUniv Buenos Aires, Sch Med, Dept Physiol & Biophys, Syst Neurosci Sect, Buenos Aires, Argentina
Pagani, Mario Rafael
Gonzalez, Laura Elisabeth
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机构:
UBA CONICET, Inst Fisiol Biol Mol Neurociencias, Buenos Aires, DF, Argentina
Univ Buenos Aires, Ciudad Univ, Fac Ciencias Exactas & Natur, Dept Fisiol Biol Mol & Celular, Buenos Aires, DF, ArgentinaUniv Buenos Aires, Sch Med, Dept Physiol & Biophys, Syst Neurosci Sect, Buenos Aires, Argentina
Gonzalez, Laura Elisabeth
Uchitel, Osvaldo Daniel
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机构:
UBA CONICET, Inst Fisiol Biol Mol Neurociencias, Buenos Aires, DF, Argentina
Univ Buenos Aires, Ciudad Univ, Fac Ciencias Exactas & Natur, Lab Fisiol Biol Mol, Ciudad Univ,Pabell II 2do Piso,C1428EHA, Buenos Aires, DF, ArgentinaUniv Buenos Aires, Sch Med, Dept Physiol & Biophys, Syst Neurosci Sect, Buenos Aires, Argentina
机构:
Minist Hlth, Phys Med & Rehabil Clin, Istanbul Training & Res Hosp, TR-34098 Istanbul, TurkeyAnadolu Univ, Fac Pharm, Dept Pharmaceut Chem, TR-26470 Eskisehir, Turkey
Sever, Hilal
Ocak, Firdevs
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机构:
Kocaeli Univ, Fac Med, TR-41001 Kocaeli, TurkeyAnadolu Univ, Fac Pharm, Dept Pharmaceut Chem, TR-26470 Eskisehir, Turkey