Improved Depth-of-Field Photoacoustic Microscopy with a Multifocal Point Transducer for Biomedical Imaging

被引:17
|
作者
Thanh Phuoc Nguyen [1 ]
Van Tu Nguyen [2 ]
Mondal, Sudip [3 ]
Van Hiep Pham [2 ]
Dinh Dat Vu [2 ]
Kim, Byung-Gak [4 ]
Oh, Junghwan [2 ,3 ]
机构
[1] Cao Thang Tech Coll, Dept Mechatron, Ho Chi Minh City 700000, Vietnam
[2] Pukyong Natl Univ, Interdisciplinary Program Biomed Mech & Elect Eng, Busan 48513, South Korea
[3] Pukyong Natl Univ, Ctr Marine Integrated Biomed Technol, Busan 48513, South Korea
[4] Pukyong Natl Univ, Coll Future Convergence, Busan 48513, South Korea
关键词
ultrasound; photoacoustic imaging; photoacoustic microscopy; biomedical imaging; multifocal point transducer; IN-VIVO; HIGH-FREQUENCY; ULTRASOUND; TOMOGRAPHY; CONTRAST; DESIGN; FABRICATION; SYSTEM;
D O I
10.3390/s20072020
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
In this study, a photoacoustic microscopy (PAM) system based on a multifocal point (MFP) transducer was fabricated to produce a large depth-of-field tissue image. The customized MFP transducer has seven focal points, distributed along with the transducer's axis, fabricated by separate spherically-focused surfaces. These surfaces generate distinct focal zones that are overlapped to extend the depth-of-field. This design allows extending the focal zone of 10 mm for the 11 MHz MFP transducer, which is a great improvement over the 0.48 mm focal zone of the 11 MHz single focal point (SFP) transducer. The PAM image penetration depths of a chicken-hemoglobin phantom using SFP and MFP transducers were measured as 5 mm and 8 mm, respectively. The significant increase in the PAM image-based penetration depth of the chicken-hemoglobin phantom was a result of using the customized MFP transducer.
引用
收藏
页数:18
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