TiO2-modified MALDI target for in vitro modeling of the oxidative biotransformation of diclofenac

被引：5
|
作者：
Gorbunov, Alexander Yu. [1 ,2 ]
Krasnov, Konstantin A. [3 ]
Bardin, Alexander A. [1 ]
Keltsieva, Olga A. [2 ,3 ]
Babakov, Vladimir N. [1 ]
Podolskaya, Ekaterina P. [2 ,3 ]
机构：
[1] Res Inst Hyg Occupat Pathol & Human Ecol, St Petersburg 188663, Russia
[2] Russian Acad Sci, Inst Analyt Instrumentat, St Petersburg 190103, Russia
[3] Inst Toxicol, St Petersburg 192019, Russia
来源：
MENDELEEV COMMUNICATIONS | 2020年 / 30卷 / 02期
关键词：
titanium dioxide; photocatalysis; photooxidation; drug metabolites; MALDI MS; FLIGHT MASS-SPECTROMETRY; METABOLISM REACTIONS; TIO2; PHOTOCATALYSIS;
D O I：
10.1016/j.mencom.2020.03.030
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The UV-induced photocatalytic oxidation in the presence of TiO2 nanoparticles (UV/TiO2-PCO) is a more adequate approach than electrochemical oxidation to simulate the oxidative metabolism of diclofenac based on the comparative analysis of oxidation products using high-resolution tandem mass spectrometry. A simple and fast high-throughput technique is proposed for modeling the oxidative metabolism, which involves UV/TiO2-PCO performed directly on a MALDI target and subsequent analysis by matrix-assisted laser desorption/ionization mass spectrometry. The ranges and yields of diclofenac oxidation products obtained by the conventional bulk UV/TiO2-PCO and the proposed on-target version are in excellent agreement.
引用
收藏
页码：220 / 222
页数：3
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