Biological evaluation of chelate-setting apatite cement using inositol phosphate

被引：3
|
作者：
Kida, K. [1 ]
Horiguchi, Y. [2 ]
Oribe, K. [2 ]
Morisue, H. [3 ]
Matsumoto, M. [3 ]
Toyama, Y. [3 ]
Aizawa, M. [1 ]
机构：
[1] Meiji Univ, Sch Sci & Technol, Dept Appl Chem, Tama Ku, 1-1-1 Higashimita, Kawasaki, Kanagawa 2148571, Japan
[2] Showa Ika Kohgyo Co Ltd, Minato Ku, Tokyo 1058751, Japan
[3] Keio Univ, Sch Med, Shinjyuku Ku, Tokyo 1608582, Japan
来源：
BIOCERAMICS, VOL 20, PTS 1 AND 2 | 2008年 / 361-363卷
关键词：
hydroxyapatite; cement; inositol phosphate; biocompatibility;
D O I：
10.4028/www.scientific.net/KEM.361-363.335
中图分类号：
TQ174 [陶瓷工业]; TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
We have successfully developed novel "chelate-setting apatite cement" using hydroxyapatite (HAp) particles surface-modified with inositol phosphate (IP6). The HAp particles surface-modified With IP6 were mixed with water (HAp/water ratio = 1.00/0.50[w/w]) to fabricate apatite cements. We have examined the biocompatibility of the apatite cement using the culture system of MC3T3-E1 cells and the rabbit model. The cell-culture test using MC3T3-E1 cells has shown that the apatite cement has noncytotoxicity. This cement has been implanted into tibiae of rabbits. When tissue response was examined histologically up to 24 weeks, new bone formation was observed around the surface of the cement. The present work demonstrates that this apatite cement is useful as a material for artificial bone grafting.
引用
收藏
页码：335 / +
页数：2
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