Hepatotoxicity after a short course of low-dose pyrazinamide

被引：0

作者：

AlSarraf, KAA ^{[1
]}

Michielsen, PP ^{[1
]}

Hauben, EI ^{[1
]}

Lefebure, A ^{[1
]}

Ramon, AM ^{[1
]}

VanMarck, EA ^{[1
]}

Pelckmans, PA ^{[1
]}

机构：

[1] UNIV INSTELLING ANTWERP, FAC MED, DIV GASTROENTEROL, B-2610 ANTWERP, BELGIUM

来源：

ACTA GASTRO-ENTEROLOGICA BELGICA | 1996年 / 59卷 / 04期

关键词：

pyrazinamide; tuberculosis; hepatotoxicity;

D O I：

暂无

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

We report on a patient who developed extensive centrolobular liver necrosis after a treatment with low-dose (25 mg/kg/d) pyrazinamide for only 4 weeks, combined with rifampicin, 600 mg/d), In the past, the patient already developed severe aminotransferase elevations under isoniazid treatment. After prompt withdrawal of the drugs, a gradual decline of the aminotransferases was observed. No signs of hepatic failure developed, Pyrazinamide has to be used with caution, even in low-dose, especially when combined with rifampicin.

引用

页码：251 / 253

页数：3

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