Synthesis of pharmaceutically active compounds containing a disubstituted piperidine framework

被引：196
|
作者：
Kallstrom, Sara [1 ]
Leino, Reko [1 ]
机构：
[1] Abo Akad Univ, Organ Chem Lab, FI-20500 Turku, Finland
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2008年 / 16卷 / 02期
基金：
芬兰科学院;
关键词：
D O I：
10.1016/j.bmc.2007.10.018
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The synthesis of pharmaceutically active compounds bearing a disubstituted piperidine framework is reviewed. Due to their frequent Occurrence in pharmaceutical research, functionalized piperidines and the synthetic methodologies used for their preparation are of considerable topical interest. The present review focuses on the synthetic pathways used for the preparation of disubstituted piperidines and also briefly covers the activity and/or usage of the same. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：601 / 635
页数：35
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