Developmental origins of chronic disease

被引:278
作者
Barker, D. J. P. [1 ,2 ]
机构
[1] Univ Southampton, Sch Med, Southampton, Hants, England
[2] Oregon Hlth & Sci Univ, Heart Res Ctr, Portland, OR 97201 USA
关键词
Fetal programming; Chronic disease; Maternal nutrition; Placenta; CORONARY-HEART-DISEASE; BODY-MASS INDEX; BLOOD-PRESSURE; INSULIN-RESISTANCE; FETAL ORIGINS; BIRTH-WEIGHT; CARDIOVASCULAR-DISEASE; MATERNAL WEIGHT; PREGNANCY; GROWTH;
D O I
10.1016/j.puhe.2011.11.014
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Coronary heart disease, type 2 diabetes, breast cancer and many other chronic diseases are unnecessary. Their occurrence is not mandated by genes passed down to us through thousands of years of evolution. Chronic diseases are not the inevitable lot of humankind. They are the result of the changing pattern of human development. We could readily prevent them, had we the will to do so. Prevention of chronic disease, and an increase in healthy ageing require improvement in the nutrition of girls and young women. Many babies in the womb in the Western world today are receiving unbalanced and inadequate diets. Many babies in the developing world are malnourished because their mothers are chronically malnourished. Protecting the nutrition and health of girls and young women should be the cornerstone of public health. Not only will this prevent chronic disease, but it will produce new generations who have better health and well-being through their lives. (C) 2011 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:185 / 189
页数:5
相关论文
共 49 条
[41]   Birth weight and risk of cardiovascular disease in a cohort of women followed up since 1976 [J].
RichEdwards, JW ;
Stampfer, MJ ;
Manson, JE ;
Rosner, B ;
Hankinson, SE ;
Colditz, GA ;
Willett, WC ;
Hennekens, CH .
BRITISH MEDICAL JOURNAL, 1997, 315 (7105) :396-400
[42]   Maternal nutrition during gestation and blood pressure in later life [J].
Roseboom, TJ ;
van der Meulen, JHP ;
van Montfrans, GA ;
Ravelli, ACJ ;
Osmond, C ;
Barker, DJP ;
Bleker, OP .
JOURNAL OF HYPERTENSION, 2001, 19 (01) :29-34
[43]  
RUSH D, 1989, FETAL GROWTH, P203
[44]   High-meat, low-carbohydrate diet in pregnancy - Relation to adult blood pressure in the offspring [J].
Shiell, AW ;
Campbell-Brown, M ;
Haselden, S ;
Robinson, S ;
Godfrey, KM ;
Barker, DJP .
HYPERTENSION, 2001, 38 (06) :1282-1288
[45]  
SILVERMAN BL, 1996, DIABETES REV, V4, P21
[46]   Fetal growth and coronary heart disease in South India [J].
Stein, CE ;
Fall, CHD ;
Kumaran, K ;
Osmond, C ;
Cox, V ;
Barker, DJP .
LANCET, 1996, 348 (9037) :1269-1273
[47]   Long-term effects on offspring of exposure of oocytes and embryos to chemical and physical agents [J].
Walker, SK ;
Hartwich, KM ;
Robinson, JS .
HUMAN REPRODUCTION UPDATE, 2000, 6 (06) :564-577
[48]  
West-Eberhard Mary Jane, 2003, pi
[49]   EFFECT OF FINITE PERIODS OF UNDERNUTRITION AT DIFFERENT AGES ON COMPOSITION AND SUBSEQUENT DEVELOPMENT OF RAT [J].
WIDDOWSON, EM ;
MCCANCE, RA .
PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 1963, 158 (972) :329-+