Novel transdermal drug delivery system with polyhydroxyalkanoate and starburst polyamidoamine dendrimer

被引：38

作者：

Wang, ZX

Itoh, Y

Hosaka, Y

Kobayashi, I

Nakano, Y

Maeda, I

Umeda, F

Yamakawa, J

Kawase, M

Yagi, K

机构：

[1] Osaka Univ, Grad Sch Pharmaceut Sci, Suita, Osaka 5650871, Japan

[2] Nitto Denko Co, Ibaraki 5678680, Japan

[3] Okayama Univ, Fac Sci, Dept Earth Sci, Okayama 7008530, Japan

来源：

JOURNAL OF BIOSCIENCE AND BIOENGINEERING | 2003年 / 95卷 / 05期

关键词：

polyhydroxyalkanoate; transdermal drug delivery system; dendrimer; tamsulosin;

D O I：

10.1263/jbb.95.541

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In search of an efficient transdermal drug delivery system (TDDS), a polyhydroxyalkanoate (PHA)-based system with a polyamidoamine dendrimer was examined. Tamsulosin was used as the model drug. The dendrimer was found to act as the weak enhancer. By adding the dendrimer, the dendrimer-containing PHA matrix achieved the clinically required amount of tamsulosin permeating through the skin model. This is also the first report of the application of PHA and dendrimer to the TDDS.

引用

页码：541 / 543

页数：3

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