Design and Synthesis of Some New Benzimidazole Containing Pyrazoles and Pyrazolyl Thiazoles as Potential Antimicrobial Agents

被引：27

作者：

Reddy, Nemallapudi Bakthavatchala ^{[1
]}

Zyryanov, Grigory V. ^{[1
,5
]}

Reddy, Guda Mallikarjuna ^{[1
,2
]}

Balakrishna, Avula ^{[3
]}

Padmaja, Adivireddy ^{[4
]}

Padmavathi, Venkatapuram ^{[4
]}

Reddy, Cirandur Suresh ^{[4
]}

Garcia, Jarem Raul ^{[2
]}

Sravya, Gundala ^{[1
]}

机构：

[1] Ural Fed Univ, Chem Engn Inst, Ekaterinburg 620002, Russia

[2] Univ Estadual Ponta Grossa, Dept Chem, BR-84030900 Ponta Grossa, Parana, Brazil

[3] Rajeev Gandhi Mem Coll Engn & Technol Autonomous, Nandyal 518501, Andhra Pradesh, India

[4] Sri Venkateswara Univ, Dept Chem, Tirupati 517502, Andhra Pradesh, India

[5] Russian Acad Sci, I Ya Postovskiy Inst Organ Synth, Ural Div, 22 S Kovalevskoy St, Ekaterinburg 620219, Russia

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2019年 / 56卷 / 02期

关键词：

2-(1H-PYRAZOL-1-YL)-THIAZOLE DERIVATIVES; APOPTOSIS; INHIBITORS; CYTOTOXICITY; OPTIMIZATION; ANTICANCER; GROWTH; SAR;

D O I：

10.1002/jhet.3435

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new class of bis heterocycles-benzimidazolyl pyrazoles were prepared from the Michael acceptor (E)-3-(1H-benzimidazol-2-yl)-1-aryl-prop-2-en-1-one. The thiamide group was exploited to develop thiazole ring on treatment with p-fluorophenacyl bromide to get tris heterocycles. All the lead compounds were tested for antimicrobial activity. The compound 7d having nitro substituent on the aromatic ring showed greater antimicrobial activity particularly against Pseudomonas aeruginosa and Penicillium chrysogenum.

引用

页码：589 / 596

页数：8

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