Poly(ether ester amide) microspheres for protein delivery: Influence of copolymer composition on technological and biological properties

被引：5
|
作者：
Ostacolo, Luisanna [1 ]
Russo, Paola [1 ]
De Rosa, Giuseppe [1 ]
La Rotonda, Maria Immacolata [1 ]
Maglio, Giovanni [2 ]
Nese, Giuseppe [2 ]
Spagnuolo, Gianrico [3 ]
Rengo, Sandro [3 ]
Oliva, Adriana [4 ]
Quaglia, Fabiana [1 ]
机构：
[1] Univ Naples Federico 2, Dept Pharmaceut & Toxicol Chem, I-80131 Naples, Italy
[2] Univ Naples Federico 2, Dept Chem Paolo Corradini, I-80126 Naples, Italy
[3] Univ Naples Federico 2, Dept Oral & Maxillofacial Sci, I-80131 Naples, Italy
[4] Univ Naples 2, Dept Biochem & Biophys F Cedrangolo, I-80138 Naples, Italy
来源：
MACROMOLECULAR BIOSCIENCE | 2008年 / 8卷 / 07期
关键词：
poly(epsilon-caprolactone); microspheres; proteins;
D O I：
10.1002/mabi.200700303
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The production of PEEA microspheres with potential as carriers for protein oral delivery is described. PEEAs with different hydrophilicity were synthesized and characterized. Experiments showed that an increase in copolymer hydrophilicity gave particles less prone to cell interaction. BSA release profiles from PEEA microspheres demonstrated that an increase in polymer hydrophilicity was useful in limiting protein burst and modulating drug delivery rate by increasing PEEA degradability. These results show that fine-tuning of the hydrophilic/hydrophobic properties of PCL is essential for the formulation protein-loaded microspheres with specific properties.
引用
收藏
页码：682 / 689
页数：8
相关论文
共 50 条
  • [21] Influence of addition of liquid crystalline copolymer of poly(aryl ether ketone) on the properties of basalt fiber/poly(ether ether ketone) composites
    Fan, Yue
    Zhang, Shu Ling
    Jiang, Zhen Hua
    Bin Wang, Gui
    HIGH PERFORMANCE POLYMERS, 2014, 26 (01) : 69 - 72
  • [22] EVALUATION OF INFLUENCE OF THE ADDITION NANOFILLERS ON THE MECHANICAL AND THERMAL PROPERTIES TERPOLYMERS ESTER-ETHER-AMIDE
    Kozlowska, A.
    Piatek-Hnat, M.
    ARCHIVES OF METALLURGY AND MATERIALS, 2014, 59 (01) : 237 - 239
  • [23] INFLUENCE OF FORMULATION METHODS ON THE INVITRO CONTROLLED RELEASE OF PROTEIN FROM POLY(ESTER) MICROSPHERES
    WANG, HT
    SCHMITT, E
    FLANAGAN, DR
    LINHARDT, RJ
    JOURNAL OF CONTROLLED RELEASE, 1991, 17 (01) : 23 - 31
  • [24] Influence of conformational parameters on physical properties of some poly(amide-ester)s
    Sava, Ion
    REVUE ROUMAINE DE CHIMIE, 2006, 51 (7-8) : 753 - 758
  • [25] Preparation and Properties of Poly(ether-ester-amide)/Poly(acrylonitrile-co-butadiene-co-styrene) Antistatic Blends
    Fu, Yishu
    Wang, Jikui
    Zhao, Guang
    Wang, Yaoxian
    Chen, Shujun
    JOURNAL OF APPLIED POLYMER SCIENCE, 2011, 122 (01) : 12 - 18
  • [26] Poly(ester amide)s based on (L)-lactic acid oligomers and -amino acids: influence of the -amino acid side chain in the poly(ester amide)s properties
    Fonseca, Ana C.
    Coelho, Jorge F. J.
    Valente, Joana F. A.
    Correia, Tiago R.
    Correia, Ilidio J.
    Gil, Maria H.
    Simoes, Pedro N.
    JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 2013, 24 (12) : 1391 - 1409
  • [27] MULTIBLOCK POLY(ETHER-ESTER-AMIDE)S BASED ON POLYAMIDE-6 AND POLY(ETHYLENE GLYCOL), .1. EFFECT OF POLYETHER SEGMENT LENGTH ON THE PROPERTIES OF POLY(ETHER-ESTER-AMIDE)S WITH VARIOUS POLYAMIDE POLYETHER RATIOS
    FAKIROV, S
    GORANOV, K
    BOSVELIEVA, E
    DUCHESNE, A
    MAKROMOLEKULARE CHEMIE-MACROMOLECULAR CHEMISTRY AND PHYSICS, 1992, 193 (09): : 2391 - 2404
  • [28] The structure properties of poly(ether ester amide) containing zinc and its blending fiber with PA6
    Guo Jing
    Shen Xinyuan
    Chen Wei
    PROCEEDINGS OF THE 2007 INTERNATIONAL CONFERENCE ON ADVANCED FIBERS AND POLYMER MATERIALS VOLS 1 AND 2, 2007, : 497 - 500
  • [29] Poly(anhydride-ester) fibers: Role of copolymer composition on hydrolytic degradation and mechanical properties
    Whitaker-Brothers, K
    Uhrich, K
    JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2004, 70A (02) : 309 - 318
  • [30] MULTIBLOCK POLY(ETHER-ESTER-AMIDE)S BASED ON POLYAMIDE-6 AND POLY(ETHYLENE GLYCOL) .2. EFFECT OF COMPOSITION AND SOFT-SEGMENT LENGTH ON THE STRUCTURE OF POLY(ETHER-ESTER-AMIDE)S AS REVEALED BY X-RAY-SCATTERING
    APOSTOLOV, AA
    BOSVELIEVA, E
    DUCHESNE, A
    GORANOV, K
    FAKIROV, S
    MAKROMOLEKULARE CHEMIE-MACROMOLECULAR CHEMISTRY AND PHYSICS, 1993, 194 (08): : 2267 - 2277
12345