Pancreatic Pain-Knowledge Gaps and Research Opportunities in Children and Adults Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop

被引：7

作者：

Aliye, Uc ^{[1
]}

Andersen, Dana K. ^{[2
]}

Apkarian, A. Vania ^{[3
,4
,5
,6
,7
]}

Bellin, Melena D. ^{[8
,9
]}

Colloca, Luana ^{[10
,11
]}

Drewes, Asbjorn M. ^{[12
]}

Dunbar, Ellyn K. ^{[13
,14
,15
]}

Forsmark, Christopher E. ^{[16
]}

Goodman, Marc T. ^{[17
]}

Kapural, Leonardo ^{[18
]}

Koob, George F. ^{[19
]}

Palermo, Tonya M. ^{[20
]}

Pandol, Stephen J. ^{[21
]}

Pasricha, Pankaj ^{[22
]}

Phillips, Anna E. ^{[13
]}

Piomelli, Daniele ^{[23
,24
,25
,26
]}

Saloman, Jami L. ^{[13
]}

Schwarzenberg, Sarah Jane ^{[27
]}

Singh, Vikesh K.

Sowa, Gwendolyn ^{[28
]}

Strouse, Thomas ^{[29
]}

Treisman, Glenn J. ^{[30
]}

Windsor, John A. ^{[31
]}

Yadav, Dhiraj ^{[13
]}

机构：

[1] Univ Iowa, Div Gastroenterol Hepatol Pancreatol & Nutr, Stead Family Dept Pediat, Iowa City, IA 52240 USA

[2] NIH, Div Digest Dis & Nutr, Natl Inst Diabetes & Digest & Kidney Dis, Bethesda, MD USA

[3] Northwestern Univ, Feinberg Sch Med, Dept Physiol, Evanston, IL 60208 USA

[4] Northwestern Univ, Feinberg Sch Med, Dept Anesthesiol, Evanston, IL 60208 USA

[5] Northwestern Univ, Feinberg Sch Med, Dept Phys Med, Evanston, IL 60208 USA

[6] Northwestern Univ, Feinberg Sch Med, Dept Rehabil, Evanston, IL 60208 USA

[7] Northwestern Univ, Feinberg Sch Med, Ctr Translat Pain Res, Evanston, IL 60208 USA

[8] Univ Minnesota, Mason Childrens Hosp, Dept Pediat, Minneapolis, MN 55417 USA

[9] Univ Minnesota, Mason Childrens Hosp, Dept Surg, Minneapolis, MN 55417 USA

[10] Univ Maryland Baltimore Cty, Sch Nurs, Dept Pain & Translat Symptom Sci, Baltimore, MD 21228 USA

[11] Univ Maryland Baltimore Cty, Sch Med, Dept Anesthesiol, Baltimore, MD 21228 USA

[12] Aalborg Univ Hosp, Dept Gastroenterol & Hepatol, Aalborg, Denmark

[13] Univ Pittsburgh, Sch Med, Div Gastroenterol Hepatol & Nutr, Dept Med, Pittsburgh, PA 15213 USA

[14] Univ Pittsburgh, Sch Med, Dept Human Genet, Pittsburgh, PA USA

[15] Univ Florida, Dept Med, Div Gastroenterol Hepatol & Nutr, Gainesville, FL USA

[16] Cedars Sinai Med Ctr, Samuel Oschin Canc Ctr, Canc Prevent & Control Program, Los Angeles, CA 90048 USA

[17] Carolinas Pain Inst, Charlotte, NC USA

[18] NIH, Natl Inst Drug, Natl Inst Alcohol Abuse & Alcoholism & Intramural, Bethesda, MD USA

[19] Univ Washington, Dept Anesthesiol & Pain Med, Seattle, WA 98195 USA

[20] Seattle Childrens Res Inst, Ctr Child Hlth Behav & Dev, Seattle, WA USA

[21] Cedars Sinai Med Ctr, Dept Med, Div Gastroenterol, Los Angeles, CA 90048 USA

[22] Johns Hopkins Univ, Div Gastroenterol & Hepatol, Dept Med, Sch Med, Baltimore, MD USA

[23] Univ Calif Irvine, Sch Med, Dept Anat, Irvine, CA 92717 USA

[24] Univ Calif Irvine, Sch Med, Dept Neurobiol, Irvine, CA 92717 USA

[25] Univ Calif Irvine, Sch Med, Dept Biol Chem, Irvine, CA 92717 USA

[26] Univ Calif Irvine, Sch Med, Dept Pharmacol, Irvine, CA 92717 USA

[27] Univ Minnesota Mason, Childrens Hosp, Div Pediat Gastroenterol Hepatol & Nutr, Minneapolis, MN USA

[28] Univ Pittsburgh, Sch Med, Dept Phys Med & Rehabil, Pittsburgh, PA USA

[29] UCLA, David Geffen Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA

[30] Johns Hopkins Univ, Sch Med, Dept Internal Med, Dept Psychiat & Behav Sci, Baltimore, MD USA

[31] Univ Auckland, Fac Med & Hlth Sci, Surg & Translat Res Ctr, Auckland, New Zealand

来源：

PANCREAS | 2021年 / 50卷 / 07期

基金：

美国国家卫生研究院;

关键词：

pancreatitis; pancreatic cancer; peripheral sensitization; central sensitization; placebo; quantitative sensory testing; QUALITY-OF-LIFE; CELIAC PLEXUS NEUROLYSIS; PEDIATRIC CHRONIC-PANCREATITIS; SPINAL-CORD STIMULATION; OPIOID PRESCRIPTIONS; SURGICAL DRAINAGE; CLINICAL-TRIALS; CANCER PATIENTS; SURVIVAL; EFFICACY;

D O I：

10.1097/MPA.0000000000001899

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

A workshop was sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases to focus on research gaps and opportunities in pancreatic pain. The event was held on July 21, 2021, and structured into 4 sessions: (1) pathophysiology; (2) biomarkers, mediators, and pharmacology of pain; (3) pain assessment; and (4) pain treatment challenges and opportunities. The current state of knowledge was reviewed; many knowledge gaps and research needs were identified that require further investigation. Common themes included the need to better understand the underlying mechanisms of pain in pancreatic diseases, the relationship of visceral neural pathways and central pain centers, the role of behavioral factors and disorders on the perception of pain, and differences in pain perception and processes in children when compared with adults. In addition, the role of genetic risk factors for pain and the mechanisms and role of placebos in pain treatment were discussed. Methods of pain assessment including quantitative sensory testing were examined, as well as the process of central sensitization of pain. Finally, newer approaches to pain management including cognitive behavioral therapy, nerve stimulation, experimental (nonopioid) drugs, and cannabinoid compounds were covered.

引用

页码：906 / 915

页数：10

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