Brigatinib in Crizotinib-Refractory ALK plus NSCLC: Central Assessment and Updates from ALTA, a Pivotal Randomized Phase 2 Trial

被引:11
|
作者
Camidge, D. Ross [1 ]
Tiseo, Marcello [2 ]
Ahn, Myung-Ju [3 ]
Reckamp, Karen [4 ]
Hansen, Karin [5 ]
Kim, Sang-We [6 ]
Huber, Rudolf [7 ]
West, Howard [8 ]
Groen, Harry [9 ]
Hochmair, Maximilian [10 ]
Leighl, Natasha [11 ]
Gettinger, Scott [12 ]
Langer, Corey [13 ]
Paz-Ares, Luis [14 ]
Smit, Egbert [15 ]
Kim, Edward [16 ]
Reichmann, William [17 ]
Clackson, Tim [17 ]
Kerstein, David [17 ]
Haluska, Frank [17 ]
Kim, Dong-Wan [18 ]
机构
[1] Univ Colorado, Ctr Canc, Aurora, CO USA
[2] Univ Hosp Parma, Med Oncol, Parma, Italy
[3] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Meidicine, Seoul, South Korea
[4] City Hope Comprehens Canc Ctr, Duarte, CA USA
[5] Odense Univ Hosp, Odense, Denmark
[6] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Oncol, Seoul, South Korea
[7] Univ Hosp Munich, Munich, Germany
[8] Swedish Canc Inst, Med Oncol, Seattle, WA USA
[9] Univ Med Ctr Groningen, Groningen, Netherlands
[10] Otto Wagner Hosp, Dept Resp & Crit Care Med, Vienna, Austria
[11] Princess Margaret Canc Ctr, Med Oncol, Toronto, ON, Canada
[12] Yale Canc Ctr, New Haven, CT USA
[13] Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA
[14] Hosp Univ Doce Octubre, Madrid, Spain
[15] Vrije Univ Amsterdam, Med Ctr, Amsterdam, Netherlands
[16] Carolinas Healthcare Syst, Levine Canc Inst, Solid Tumor Oncol, Charlotte, NC USA
[17] ARIAD Pharmaceut Inc, Cambridge, MA 02139 USA
[18] Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea
关键词
ALK; brigatinib; NSCLC; TKI;
D O I
10.1016/j.jtho.2016.11.1643
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
P3.02a-013
引用
收藏
页码:S1167 / S1169
页数:3
相关论文
共 50 条
  • [21] Brigatinib (BRG) in ALK plus crizotinib (CRZ)-refractory non-small cell lung cancer (NSCLC): Final results of the phase 1/2 and phase 2 (ALTA) trials.
    Gettinger, Scott N.
    Huber, Rudolf M.
    Kim, Dong-Wan
    Bazhenova, Lyudmila
    Hansen, Karin Holmskov
    Tiseo, Marcello
    Langer, Corey J.
    Paz-Ares, Luis G.
    West, Howard
    Reckamp, Karen L.
    Weiss, Glen J.
    Smit, Egbert F.
    Hochmair, Maximilian
    Kim, Sang-We
    Ahn, Myung-Ju
    Kim, Edward S.
    Groen, Harry J. M.
    Pye, Joanna
    Vranceanu, Florin
    Camidge, D. Ross
    JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (15)
  • [22] Updated Results from the Phase 3 ALTA-1L Trial of Brigatinib (BRG) vs. Crizotinib (CRZ) in ALK Inhibitor-Naive Advanced ALK plus NSCLC
    Griesinger, Frank
    Camidge, D. Ross
    Kim, Hye Ryun
    Ahn, Myung-Ju
    Yang, James Chih-Hsin
    Han, Ji Youn
    Hochmair, Maximilian
    Lee, Hyeong
    Delmonte, Angelo
    Garcia Compelo, Maria Rosario
    Kim, Dong-Wan
    Felip, Enriqueta
    Califano, Raffaele
    Spire, Alexander
    Gettinger, Scott N.
    Tiseo, Marcello
    Lin, Huamao M.
    Ni, Quanhong
    Zhang, Pingkuan
    Popat, Sanjay
    ONCOLOGY RESEARCH AND TREATMENT, 2020, 43 : 232 - 232
  • [23] Brigatinib (BRG) vs crizotinib (CRZ) in ALK TKI-naive ALK plus NSCLC: Final results from ALTA-1L
    Popat, S.
    Kim, H. R.
    Ahn, M-J.
    Yang, J. C.
    Han, J-Y.
    Hochmair, M. J.
    Lee, K. H.
    Delmonte, A.
    Garcia Campelo, M. R.
    Kim, D-W.
    Griesinger, F.
    Felip, E.
    Califano, R.
    Spira, A.
    Gettinger, S. N.
    Tiseo, M.
    Lin, H. M.
    Liu, Y.
    Vranceanu, F.
    Camidge, D. R.
    ANNALS OF ONCOLOGY, 2021, 32 : S954 - S955
  • [24] Brigatinib (BRG) vs Crizotinib (CRZ) in Patients (Pts) With ALK Inhibitor-Naive Advanced ALK plus NSCLC from ALTA-1L
    Yang, James C. H.
    Kim, Hye R.
    Ahn, Myung-Ju
    Han, Ji-Youn
    Hochmair, Maximilian J.
    Lee, Ki H.
    Delmonte, Angelo
    Garcia Campelo, Maria R.
    Kim, Dong-Wan
    Felip, Enriqueta
    Califano, Raffaele
    Spira, Alexander
    Gettinger, Scott
    Tiseo, Marcello
    Haney, Jeff
    Kerstein, David
    Popat, Sanjay
    Camidge, D. R.
    ANNALS OF ONCOLOGY, 2019, 30
  • [25] Brigatinib Versus Alectinib in ALK-Positive NSCLC After Disease Progression on Crizotinib: Results of Phase 3 ALTA-3 Trial
    Yang, James Chih-Hsin
    Liu, Geoffrey
    Lu, Shun
    He, Jianxing
    Burotto, Mauricio
    Ahn, Myung-Ju
    Kim, Dong-Wan
    Liu, Xiaoqing
    Zhao, Yanqiu
    Vincent, Sylvie
    Yin, Jiani
    Ma, Xin
    Lin, Huamao M.
    Popat, Sanjay
    JOURNAL OF THORACIC ONCOLOGY, 2023, 18 (12) : 1743 - 1755
  • [26] Brigatinib vs crizotinib in patients with ALK inhibitor-naive advanced ALK1 NSCLC: Updated results from the phase III ALTA-1L trial
    Camidge, R.
    Kim, H. R.
    Ahn, M-J.
    Yang, J. C-H.
    Han, J-Y.
    Hochmair, M. J.
    Lee, K. H.
    Delmonte, A.
    Garcia Campelo, M. R.
    Kim, D-W.
    Griesinger, F.
    Felip, E.
    Califano, R.
    Spira, A.
    Gettinger, S.
    Tiseo, M.
    Ni, Q.
    Zhang, P.
    Popat, S.
    ANNALS OF ONCOLOGY, 2019, 30
  • [27] Brigatinib Versus Crizotinib in ALK Inhibitor-Naive Advanced ALK-Positive NSCLC: Final Results of Phase 3 ALTA-1L Trial
    Camidge, D. Ross
    Kim, Hye Ryun
    Ahn, Myung-Ju
    Yang, James C. H.
    Han, Ji-Youn
    Hochmair, Maximilian J.
    Lee, Ki Hyeong
    Delmonte, Angelo
    Campelo, Maria Rosario Garcia
    Kim, Dong-Wan
    Griesinger, Frank
    Felip, Enriqueta
    Califano, Raffaele
    Spira, Alexander I.
    Gettinger, Scott N.
    Tiseo, Marcello
    Lin, Huamao M.
    Liu, Yuyin
    Vranceanu, Florin
    Niu, Huifeng
    Zhang, Pingkuan
    Popat, Sanjay
    JOURNAL OF THORACIC ONCOLOGY, 2021, 16 (12) : 2091 - 2108
  • [28] Depth of Target Lesion Response to Brigatinib and Its Association With Outcomes in Patients With ALK plus NSCLC in the ALTA Trial
    Camidge, D. R.
    Tiseo, M.
    Ahn, M.
    Reckamp, K.
    Hansen, K.
    Kim, S.
    Huber, R.
    West, H.
    Groen, H.
    Hochmair, M.
    Leighl, N.
    Gettinger, S.
    Langer, C.
    Paz-Ares, L.
    Smit, E.
    Kim, E.
    Reichmann, W.
    Kerstein, D.
    Kim, D.
    JOURNAL OF THORACIC ONCOLOGY, 2017, 12 (11) : S1892 - S1892
  • [29] Brigatinib (BRG) in patients (pts) with ALK plus non-small cell lung cancer (NSCLC): Updates from a phase 1/2 trial.
    Bazhenova, Lyudmila
    Gettinger, Scott N.
    Langer, Corey J.
    Salgia, Ravi
    Gold, Kathryn A.
    Rosell, Rafael
    Shaw, Alice Tsang
    Weiss, Glen J.
    Haney, Jeff
    Rivera, Victor M.
    Kerstein, David
    Camidge, D. Ross
    JOURNAL OF CLINICAL ONCOLOGY, 2017, 35
  • [30] Brigatinib (AP26113) Efficacy and Safety in ALK plus NSCLC: Phase 1/2 Trial Results
    Gettinger, Scott N.
    Bazhenova, Lyudmila
    Salgia, Ravi
    Langer, Corey J.
    Gold, Kathryn A.
    Rosell, Rafael
    Shaw, Alice
    Weiss, Glen J.
    Dorer, David J.
    Rivera, Victor M.
    Conlan, Maureen G.
    Kerstein, David
    Camidge, Ross
    JOURNAL OF THORACIC ONCOLOGY, 2015, 10 (09) : S238 - S239