Antibody-free detection of protein phosphorylation using intrinsic peroxidase-like activity of platinum/carbon dot hybrid nanoparticles

被引：21

作者：

Wang, Yuzhen ^{[1
,2
,3
]}

Qi, Wenjin ^{[4
]}

Song, Yujun ^{[1
]}

机构：

[1] Nanjing Univ, Coll Engn & Appl Sci, Dept Biomed Engn, Nanjing 210093, Jiangsu, Peoples R China

[2] Houston Methodist Hosp, Res Inst, Dept Nanomed, Houston, TX 77030 USA

[3] Cornell Univ, Weill Med Coll, New York, NY 10065 USA

[4] Kunming Med Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Kunming 660032, Yunnan, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 51期

基金：

中国国家自然科学基金;

关键词：

MASS-SPECTROMETRY; KINASE; RECEPTOR; PHOSPHOPROTEOME; INHIBITION; RADIATION; CANCER; CELLS;

D O I：

10.1039/c6cc02771g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Platinum and carbon dot hybrid nanomaterials are prepared for visualized detection of phosphoproteins without the need for antibodies or enzymes. This new strategy can be used for colorimetric detection of phosphoproteins induced by protein kinase as well as protein phosphorylation sites on cell membranes.

引用

页码：7994 / 7997

页数：4

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