Microsatellite-Stable Colorectal Cancer (MSS CRC) Shows Enrichment for Loss of Neoantigenic Mutations (NAMs) Compared to CRC with Microsatellite Instability (MSI)

被引:0
|
作者
Nadhamuni, V. Srirangam [1 ]
Lakatos, E. [1 ]
Househam, J. [1 ]
Heide, T. [2 ]
Cresswell, G. [2 ]
Spiteri, I. [2 ]
Mossner, M. [1 ]
Kimberley, C. [1 ]
Ortiz, L. Zapata [2 ]
James, C. [2 ]
Lynn, C. [2 ]
Berner, A. [1 ]
Costa, H. [3 ]
Mitchinson, M. [3 ]
Jansen, M. [3 ]
Caravagna, G. [2 ,4 ]
Rodriguez-Justo, M. [3 ]
Shibata, D. [5 ]
Bridgewater, J. [3 ]
Baker, A-M [1 ]
Sottoriva, A. [2 ]
Graham, T. [1 ]
机构
[1] Queen Mary Univ London, Barts Canc Inst, London, England
[2] Inst Canc Res, London, England
[3] UCL, London, England
[4] Univ Trieste, Trieste, Italy
[5] Univ Southern Calif, Los Angeles, CA 90007 USA
来源
JOURNAL OF PATHOLOGY | 2021年 / 255卷
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:S33 / S33
页数:1
相关论文
共 50 条
  • [21] Analysis of molecular mechanisms of the frequency of mutations in the 3′ -UTR in human colorectal cancer (CRC) with microsatellite instability (MSI) using the novel systematic biology technologies
    Yuan, Ziqiang
    Tafer, Hakim
    Cai, Dongqing
    Azarbay, Azzie
    Ady, Justin
    Mariadason, John
    Hofacker, Ivo
    Weber, Thomas K.
    CANCER RESEARCH, 2009, 69
  • [22] Coexistence of Microsatellite Stable (MSS) and Instable Colorectal Cancer (CRC) Primary Colon Cancers: A Case Report and Brief Review of Literature
    Wassimi, S.
    AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2020, 154 : S78 - S78
  • [23] High Concordance Between Mismatch Repair Protein Immunohistochemistry (MMR IHC) and Microsatellite Instability (MSI) Testing in Colorectal Cancer (CRC)
    Mowers, Jonathan
    Greenson, Joel
    Betz, Bryan
    Brown, Noah
    MODERN PATHOLOGY, 2019, 32
  • [24] High Concordance Between Mismatch Repair Protein Immunohistochemistry (MMR IHC) and Microsatellite Instability (MSI) Testing in Colorectal Cancer (CRC)
    Mowers, Jonathan
    Greenson, Joel
    Betz, Bryan
    Brown, Noah
    LABORATORY INVESTIGATION, 2019, 99
  • [25] Comparative analysis of the tumor immune microenvironment (TIME) in primary and metastatic sites of microsatellite stable (MSS) and microsatellite instability-high (MSI) colorectal cancer
    Fakih, M.
    Ye, J.
    Wang, C.
    Egelston, C.
    Huang, M.
    Mercer, J.
    Thompson, M. A.
    Gong, J.
    ANNALS OF ONCOLOGY, 2023, 34 : S422 - S422
  • [26] Distinctive Spatiotemporal Stability of Somatic Mutations in Metastasized Microsatellite-stable Colorectal Cancer
    Jesinghaus, Moritz
    Wolf, Thomas
    Pfarr, Nicole
    Muckenhuber, Alexander
    Ahadova, Aysel
    Warth, Arne
    Goeppert, Benjamin
    Sers, Christine
    Kloor, Matthias
    Endris, Volker
    Stenzinger, Albrecht
    Weichert, Wilko
    AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2015, 39 (08) : 1140 - 1147
  • [27] MECHANISMS FOR LOSS OF BETA2-MICROGLOBULIN IN CRC IN COLON CANCER WITH MICROSATELLITE INSTABILITY
    Ruiz-Cabello, Francisco
    Lupez, Marta
    Concha, Angel
    Fraga, Maximo
    Bustamante, Luis
    Jimenez, Pilar
    Garrido, Federico
    TISSUE ANTIGENS, 2013, 81 (05): : 321 - 321
  • [28] Functional impact of somatic mutations in early-onset (EO) versus average onset (AO) microsatellite stable (MSS) stage III colorectal cancer (CRC).
    Harrold, Emily
    Solter, Mark
    Walch, Henry S.
    Chatila, Walid Khaled
    Keane, Fergus
    Lumish, Melissa Amy
    Yaeger, Rona
    Weiss, Jill A.
    Palmaira, Randze Lerie
    Krishnan, Asha
    Diaz, Luis A.
    Stadler, Zsofia Kinga
    Cercek, Andrea
    JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (16)
  • [29] A phase 1b study of NC410 in combination with pembrolizumab in immune checkpoint inhibitor (ICI) naive, and refractory microsatellite stable (MSS)/microsatellite instability-low (MSI-L) colorectal cancer (CRC) and ovarian cancer.
    Christenson, Eric
    Mahadevan, Daruka
    Kazmi, Syed Mohammad Ali
    Manda, Sudhir
    Sohal, Davendra
    Hutson, Thomas E.
    Fu, Siqing
    Martz, Ashley
    Kordahi, Stephanie
    Barbu, Emilia Alina
    Flies, Dallas
    Langermann, Solomon
    Chisamore, Michael Jon
    Gutierrez, Martin
    Matrana, Marc Ryan
    Spira, Alex
    Wadlow, Raymond Couric
    Guha, Udayan
    Myint, Han
    Le, Dung T.
    JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (16)
  • [30] THE HUMANISTIC BURDEN OF MICROSATELLITE INSTABILITY-HIGH (MSI-H) COLORECTAL CANCER (CRC) AND METASTATIC CRC (MCRC) PATIENTS TREATED WITH SUBSEQUENT LINE THERAPY: A SYSTEMATIC REVIEW
    Kohn, C. G.
    Nguyen, E.
    Miller, J. D.
    Nwokeji, E.
    Laurie, M.
    Kamble
    Khan, T.
    Masood, A.
    Korytowsky, B.
    VALUE IN HEALTH, 2017, 20 (09) : A454 - A454