Epithelial to Mesenchymal Transition History: From Embryonic Development to Cancers

被引：29
|
作者：
Lachat, Camille [1 ]
Peixoto, Paul [1 ,2 ]
Hervouet, Eric [1 ,2 ,3 ]
机构：
[1] Univ Bourgogne Franche Comte, INSERM, EFS BFC, UMR RIGHT 1098, F-25000 Besancon, France
[2] Univ Bourgogne Franche Comte, EPIgenet & GENe EXPress Tech Platform EPIGENExp, F-25000 Besancon, France
[3] Univ Bourgogne Franche Comte, DImaCell Platform, F-25000 Besancon, France
来源：
BIOMOLECULES | 2021年 / 11卷 / 06期
关键词：
EMT; development; cancer; TRANSCRIPTION FACTOR SNAIL; CADHERIN GENE-EXPRESSION; MEDIAL EDGE EPITHELIUM; MAMMARY STEM-CELLS; MIR-200; FAMILY; UP-REGULATION; MOLECULAR-MECHANISMS; SOMITIC SEGMENTATION; FIBROBLASTS DERIVE; REPRESSORS ZEB1;
D O I：
10.3390/biom11060782
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Epithelial to mesenchymal transition (EMT) is a process that allows epithelial cells to progressively acquire a reversible mesenchymal phenotype. Here, we recount the main events in the history of EMT. EMT was first studied during embryonic development. Nowadays, it is an important field in cancer research, studied all around the world by more and more scientists, because it was shown that EMT is involved in cancer aggressiveness in many different ways. The main features of EMT's involvement in embryonic development, fibrosis and cancers are briefly reviewed here.
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页数：18
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