Epithelial to Mesenchymal Transition History: From Embryonic Development to Cancers

被引：29
|
作者：
Lachat, Camille [1 ]
Peixoto, Paul [1 ,2 ]
Hervouet, Eric [1 ,2 ,3 ]
机构：
[1] Univ Bourgogne Franche Comte, INSERM, EFS BFC, UMR RIGHT 1098, F-25000 Besancon, France
[2] Univ Bourgogne Franche Comte, EPIgenet & GENe EXPress Tech Platform EPIGENExp, F-25000 Besancon, France
[3] Univ Bourgogne Franche Comte, DImaCell Platform, F-25000 Besancon, France
来源：
BIOMOLECULES | 2021年 / 11卷 / 06期
关键词：
EMT; development; cancer; TRANSCRIPTION FACTOR SNAIL; CADHERIN GENE-EXPRESSION; MEDIAL EDGE EPITHELIUM; MAMMARY STEM-CELLS; MIR-200; FAMILY; UP-REGULATION; MOLECULAR-MECHANISMS; SOMITIC SEGMENTATION; FIBROBLASTS DERIVE; REPRESSORS ZEB1;
D O I：
10.3390/biom11060782
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Epithelial to mesenchymal transition (EMT) is a process that allows epithelial cells to progressively acquire a reversible mesenchymal phenotype. Here, we recount the main events in the history of EMT. EMT was first studied during embryonic development. Nowadays, it is an important field in cancer research, studied all around the world by more and more scientists, because it was shown that EMT is involved in cancer aggressiveness in many different ways. The main features of EMT's involvement in embryonic development, fibrosis and cancers are briefly reviewed here.
引用
收藏
页数：18
相关论文
共 50 条
  • [1] From shape-shifting embryonic cells to oncology: The fascinating history of epithelial mesenchymal transition
    Akhurst, Rosemary J.
    SEMINARS IN CANCER BIOLOGY, 2023, 96 : 100 - 114
  • [2] Epithelial Mesenchymal Transition in Aggressive Lung Cancers
    Mittal, Vivek
    LUNG CANCER AND PERSONALIZED MEDICINE: NOVEL THERAPIES AND CLINICAL MANAGEMENT, 2016, 890 : 37 - 56
  • [3] The miRNAs and Epithelial-Mesenchymal Transition in Cancers
    Lin, Ching-Wen
    Kao, Shih-Han
    Yang, Pan-Chyr
    CURRENT PHARMACEUTICAL DESIGN, 2014, 20 (33) : 5309 - 5318
  • [4] Aggressiveness of epithelial cancers is independent of epithelial-to-mesenchymal transition
    Badve, Sunil S.
    Neelamraju, Yaseswini
    Goswami, Chirayu P.
    Gu, Xiaoping
    Nallamothu, Gouthami
    Gu, Yuan
    Vieth, Edyta
    Janga, Sarath C.
    Ryan, Michael
    Gokmen-Polar, Yesim
    CANCER RESEARCH, 2018, 78 (04)
  • [5] Epithelial Mesenchymal Transition in Embryonic Development, Tissue Repair and Cancer: A Comprehensive Overview
    Kim, Do Hyung
    Xing, Tiaosi
    Yang, Zhibin
    Dudek, Ronald
    Lu, Qun
    Chen, Yan-Hua
    JOURNAL OF CLINICAL MEDICINE, 2018, 7 (01)
  • [6] Epithelial-Mesenchymal Transition in Skin Cancers: A Review
    Hodorogea, Anastasia
    Calinescu, Andreea
    Antohe, Mihaela
    Balaban, Mihaela
    Nedelcu, Roxana Ioana
    Turcu, Gabriela
    Ion, Daniela Adriana
    Badarau, Ioana Anca
    Popescu, Catalin Mihai
    Popescu, Raluca
    Popp, Cristiana
    Cioplea, Mirela
    Nichita, Luciana
    Hulea, Ionela
    Brinzea, Alice
    ANALYTICAL CELLULAR PATHOLOGY, 2019, 2019
  • [7] Immunoediting of cancers may lead to epithelial to mesenchymal transition
    Knutson, Keith L.
    Lu, Hailing
    Stone, Brad
    Reiman, Jennifer M.
    Behrens, Marshall D.
    Prosperi, Christine M.
    Gad, Ekram A.
    Smorlesi, Arianna
    Disis, Mary L.
    JOURNAL OF IMMUNOLOGY, 2006, 177 (03): : 1526 - 1533
  • [8] Immunoediting of cancers may lead to epithelial to mesenchymal transition
    Reiman, Jennifer M.
    Behrens, Marshall D.
    Disis, Mary L.
    Knutson, Keith L.
    JOURNAL OF IMMUNOTHERAPY, 2006, 29 (06) : 681 - 681
  • [9] Mesenchymal to epithelial transition in development and disease
    Chaffer, Christine L.
    Thompson, Erik W.
    Williams, Elizabeth D.
    CELLS TISSUES ORGANS, 2007, 185 (1-3) : 7 - 19
  • [10] Mesenchymal–epithelial transition in development and reprogramming
    Duanqing Pei
    Xiaodong Shu
    Ama Gassama-Diagne
    Jean Paul Thiery
    Nature Cell Biology, 2019, 21 : 44 - 53
12345