Excited-state locked amino analogues of the green fluorescent protein chromophore with a giant Stokes shift

被引：8

作者：

Zaitseva, Snizhana O. ^{[1
]}

Farkhutdinova, Dilara A. ^{[2
]}

Baleeva, Nadezhda S. ^{[1
]}

Smirnov, Alexander Yu. ^{[1
]}

Zagudaylova, Marina B. ^{[1
]}

Shakhov, Aleksander M. ^{[3
]}

Astafiev, Artyom A. ^{[2
]}

Baranov, Mikhail S. ^{[1
,4
]}

Bochenkova, Anastasia V. ^{[2
]}

机构：

[1] Russian Acad Sci, Inst Bioorgan Chem, Miklukho Maklaya 16-10, Moscow 117997, Russia

[2] Lomonosov Moscow State Univ, Dept Chem, Leninskie Gory 1-3, Moscow 119991, Russia

[3] RAS, Semenov Inst Chem Phys, Moscow, Russia

[4] Pirogov Russian Natl Res Med Univ, Ostrovitianov 1, Moscow 117997, Russia

来源：

RSC ADVANCES | 2019年 / 9卷 / 66期

基金：

俄罗斯基础研究基金会;

关键词：

FLUOROPHORES; BIOMOLECULES;

D O I：

10.1039/c9ra08808c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We design a novel class of excited-state locked GFP chromophores by introducing an amine group at the double exo-bond and a difluoroboryl bridge. We show that these chromophores intrinsically exhibit a very large Stokes shift of 1 eV. Further tuning through chemical modifications of their aryl substituents makes them environmentally sensitive.

引用

页码：38730 / 38734

页数：5

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