Comparison of desogestrel/ethinyl estradiol plus spironolactone versus cyproterone acetate/ethinyl estradiol in the treatment of polycystic ovary syndrome: A randomized controlled trial

AimTo compare the effects of ethinyl estradiol (EE) 30mcg/desogestrel 150mcg plus spironolactone 25mg/day (group A) versus EE 35mcg/cyproterone acetate 2mg (group B) on hyperandrogenism and metabolism in PCOS. MethodsThis was a randomized clinical study. Eighteen women in groups A and B received medications for three cycles. Acne score, androgens and metabolic parameters were assessed before and after treatment. ResultsOne and two women in groups A and B, respectively, were excluded from the study. Both groups had significantly decreased acne score and free androgen index, and increased sex hormone-binding globulin levels. Cholesterol and high-density lipoprotein were significantly increased in group B, and androstenedione was significantly decreased in group A. The regular withdrawal bleeding was obtained in both groups. ConclusionBoth regimens had quite similar efficacy on hyperandrogenism after three cycles of therapy and without any changes in metabolic parameters.