Copper catalyzed aerobic oxidative amination of 3,4-dihydroquinoxalin-2(1H)-ones

被引：6
|
作者：
Wan, Shuocheng [1 ]
Wang, Jie [1 ]
Huo, Congde [1 ]
机构：
[1] Northwest Normal Univ, Coll Chem & Chem Engn, Gansu Int Sci & Technol Cooperat, Base Water Retent Chem Funct Mat, Lanzhou 730070, Gansu, Peoples R China
来源：
TETRAHEDRON LETTERS | 2021年 / 78卷
基金：
中国国家自然科学基金;
关键词：
Aerobic; Amination; Oxidation; Copper; 3-Aminoquinoxalinones; 3,4-Dihydroquinoxalin-2(1H)-ones; QUINOXALINE DERIVATIVES; BOND FORMATION; INHIBITORS; DESIGN;
D O I：
10.1016/j.tetlet.2021.153271
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A copper catalyzed aerobic sp(3) C-H amination of 3,4-dihydroquinoxalin-2(1H)-ones is developed. This protocol provides a concise method to access 3-aminoquinoxalinone derivatives with good functional-group tolerances, utilizing primary and secondary aliphatic amines as nitrogen sources under mild and simple reaction conditions. It provides a practical approach to the synthesis of pharmaceutical active 3-aminoquinoxalinones. (C) 2021 Elsevier Ltd. All rights reserved.
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页数：4
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