Association of Single-Nucleotide Polymorphisms in Immune-Related Genes with Development of Dengue Hemorrhagic Fever in a Mexican Population

被引:10
|
作者
Berenice Vargas-Castillo, Angelica [1 ,2 ]
Ruiz-Tovar, Karina [3 ]
Vivanco-Cid, Hector [4 ]
Quiroz-Cruz, Sarai [2 ]
Escobar-Gutierrez, Alejandro [3 ]
Francisco Cerna-Cortes, Jorge [1 ]
Vaughan, Gilberto [5 ]
Fonseca-Coronado, Salvador [2 ]
机构
[1] Inst Politecn Nacl, Escuela Nacl Ciencias Biol, Dept Microbiol, Lab Microbiol Mol, Ciudad De Mexico, Mexico
[2] Univ Nacl Autonoma Mexico, Fac Estudios Super Cuautitlan, Unidad Invest Multidisciplinaria, Lab Inmunobiol Enfermedades Infecciosas, Carretera Cuautitlan Teoloyucan Km 2-5, San Sebastian Xhala 54714, Cuautitlan Izca, Mexico
[3] Secretaria Salud, Inst Diagnost & Referencia Epidemiol, Coordinac Invest Inmunol, Ciudad De Mexico, Mexico
[4] Univ Veracruzana, Inst Invest Med Biol, Xalapa, Veracruz, Mexico
[5] Univ Anahuac Mexico Norte, Fac Ciencias Salud, Ctr Invest Ciencias Salud CICSA, Naucalpan De Juarez, Estado De Mexic, Mexico
关键词
dengue; single-nucleotide polymorphisms; TNF-alpha; immune-related genes; Mexican population; NECROSIS-FACTOR-ALPHA; FC-GAMMA-RIIA; DC-SIGN; CLINICAL SYMPTOMS; CUBAN POPULATION; VIRUS-INFECTION; CD209; PROMOTER; RECEPTOR-II; IFN-LAMBDA; INTERFERON;
D O I
10.1089/vim.2017.0069
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Single-nucleotide polymorphisms (SNPs) occurring in immune-related genes have been associated with risk or protection for development of dengue, depending on ethnicity. Here, we genotyped seven SNPs located in immune response-related genes to identify their association with severe forms of dengue in patients from an endemic region in Mexico. One hundred and thirty-eight patients with dengue fever (DF), thirty-one dengue hemorrhagic fever (DHF) patients, as well as 304 healthy donors were genotyped by using a TaqMan-based approach. SNP analysis, including rs1800629 (TNF), rs4804803 (CD209), rs2780831 (JAK1), rs1801274 (FCGR2A), rs231775 (CTLA4), rs12979860, and rs8099917 (IFNL3), was performed. The rs1800629A-allele in the TNF gene was associated with an increased risk of DHF (OR=3.4, CI=1.235-9.284 p=0.0212) whereas SNPs rs4804803, rs2780831, rs1801274, rs231775, rs12979860, and rs8099917 showed no association in this cohort. These results show that allelic variations in TNF can play an important role in the development of DHF. However, the lack of association between all remaining SNPs and DHF suggests that the genetic background might directly modify the role of these immune-related molecules, leading to the milder illness often observed in a Mexican population.
引用
收藏
页码:249 / 255
页数:7
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