Synthesis of highly substituted tetrahydroquinolines using ethyl cyanoacetate via aza-Michael-Michael addition

被引：4
|
作者：
Palanimuthu, Arunan [2 ]
Chen, Chinpiao [1 ,2 ]
Lee, Gene-Hsian [3 ]
机构：
[1] Tzu Chi Univ Sci & Technol, Dept Nursing, Hualien 970, Taiwan
[2] Natl Dong Hwa Univ, Dept Chem, Soufeng, Hualien 974, Taiwan
[3] Natl Taiwan Univ, Coll Sci, Instrumentat Ctr, Taipei 106, Taiwan
来源：
RSC ADVANCES | 2020年 / 10卷 / 23期
关键词：
CONSTRUCTION; INHIBITORS; ACID; EFFICIENT; DESIGN; SITE;
D O I：
10.1039/d0ra01264e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A three-component cascade reaction involving 2-alkenyl aniline, aldehydes, and ethyl cyanoacetate in the presence of DBU to synthesize highly substituted 1,2,3,4-tetrahydroquinolines is reported. The reaction proceeded through the Knoevenagel condensation of ethyl cyanoacetate with aldehydes followed by the aza-Michael-Michael addition with 2-alkenyl anilines to prepare the tetrahydroquinoline scaffolds.
引用
收藏
页码：13591 / 13600
页数：10
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