Clinical retrospective analysis of 20 cases with digestive tract multiple primary malignant neoplasms

Digestive tract multiple primary malignant neoplasms (MPMN) are relatively rare, but their diagnostic rate has increased because of endoscopic development. The aim of this study was to determine the clinical features, treatment factors, and prognosis of patients with digestive tract MPMNs. In order to improve its diagnosis and therapy. Clinical data of 20 patients with digestive tract MPMNs who were admitted to the department of gastroenterology, Zhongda Hospital affiliated to Southeast University from January 2012 to January 2017 were collected and analyzed retrospectively. We found that among 20 patients with MPMNs, 4 (20%) patients had synchronous tumors and 16 (80%) patients had metachronous tumors. And the average age in the SMPMN and MMPMN group was 63 and 54.9 years old respectively. The most common locations of MPMNs were esophagus, cardia, stomach, rectum and colon. The median survival time of SMPMN was 30 months, longer than that MMPMN (16 months); The first and second primary tumors all treated with endoscopic submucosal dissection (ESD) has a longer survival time than those treated with else. The results of the present study demonstrate that patients with high risk factors for gastrointestinal malignancy neoplasms should be performed with gastrointestinal endoscopy. Early diagnosis and treatment thereby do improve the prognosis of patients with digestive tract MPMNs.