Can AlphaFold2 predict the impact of missense mutations on structure?

被引：177
|
作者：
Buel, Gwen R. [1 ]
Walters, Kylie J. [1 ]
机构：
[1] NCI, Struct Biol Ctr, Ctr Canc Res, NIH, Frederick, MD 21701 USA
来源：
NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2022年 / 29卷 / 01期
基金：
美国国家卫生研究院;
关键词：
BRCA1;
D O I：
10.1038/s41594-021-00714-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：1 / 2
页数：2
相关论文
共 50 条
  • [21] Toward the appropriate interpretation of Alphafold2
    Xu, Tian
    Xu, Qin
    Li, Jianyong
    FRONTIERS IN ARTIFICIAL INTELLIGENCE, 2023, 6
  • [22] Sequence clustering confounds AlphaFold2
    Joseph W. Schafer
    Myeongsang Lee
    Devlina Chakravarty
    Joseph F. Thole
    Ethan A. Chen
    Lauren L. Porter
    Nature, 2025, 638 (8051) : E8 - E12
  • [23] Structure of Heme-binding Pocket in Heme Protein is Generally Rigid and can be Predicted by AlphaFold2
    Kondo, Hiroko X.
    Kanematsu, Yusuke
    Takano, Yu
    CHEMISTRY LETTERS, 2022, 51 (07) : 704 - 708
  • [24] AlphaFold2 and the future of structural biology
    Patrick Cramer
    Nature Structural & Molecular Biology, 2021, 28 : 704 - 705
  • [25] AlphaFold2 and the future of structural biology
    Cramer, Patrick
    NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2021, 28 (09) : 704 - 705
  • [26] Outer membrane β-barrel structure prediction through the lens of AlphaFold2
    Topitsch, Annika
    Schwede, Torsten
    Pereira, Joana
    PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2024, 92 (01) : 3 - 14
  • [27] Assessing structure and dynamics of AlphaFold2 prediction of GeoCas9
    Arantes, Pablo R.
    Nierzwicki, Lukasz
    Belato, Helen
    D'Ordine, Alexandra M.
    Jogl, Gerwald
    Lisi, George
    Palermo, Giulia
    BIOPHYSICAL JOURNAL, 2022, 121 (03) : 45 - 45
  • [28] Using Alphafold2 to Predict the Structure of the Gp5/M Dimer of Porcine Respiratory and Reproductive Syndrome Virus
    Veit, Michael
    Gadalla, Mohamed Rasheed
    Zhang, Minze
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (21)
  • [29] Protein Loop Modeling Using AlphaFold2
    Wang, Junlin
    Wang, Wenbo
    Shang, Yi
    IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS, 2023, 20 (05) : 3306 - 3313
  • [30] A language model beats alphafold2 on orphans
    Jennifer M. Michaud
    Ali Madani
    James S. Fraser
    Nature Biotechnology, 2022, 40 : 1576 - 1577
12345