A one-pot procedure for methylenating carbonyl compounds using the Nysted reagent and titanocene dichloride

被引：5
|
作者：
Haahr, Adam [1 ]
Rankovic, Zoran [2 ]
Hartley, Richard C. [1 ]
机构：
[1] Univ Glasgow, Dept Chem, Glasgow G12 8QQ, Lanark, Scotland
[2] MSD, Newhouse ML1 5SH, England
来源：
TETRAHEDRON LETTERS | 2011年 / 52卷 / 23期
关键词：
Titanium; Schrock carbene; Carbenoid; Zinc; Microwave-assisted reactions; ANALOGS; ALKYLIDENATION; OLEFINATION; ACID; RING;
D O I：
10.1016/j.tetlet.2011.04.017
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The combination of the Nysted reagent and titanocene dichloride methylenates aldehydes and ketones to give alkenes, and in a microwave-assisted process, esters and lactones give enol ethers. The methylenating agent in this one-pot procedure is presumed to be titanocene methylidene, which is the same reactive intermediate as that generated from Tebbe, Petasis and Grubbs reagents, each of which have to be prepared before use. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3020 / 3022
页数：3
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