An 'OFF-ON' fluorescent probe for specially recognize on Cys and its application in bioimaging

被引：60
|
作者：
Yang, Yutao [1 ]
Huo, Fangjun [2 ]
Yin, Caixia [1 ]
Chao, Jianbin [2 ]
Zhang, Yongbin [2 ]
机构：
[1] Shanxi Univ, Inst Mol Sci, Taiyuan 030006, Peoples R China
[2] Shanxi Univ, Res Inst Appl Chem, Taiyuan 030006, Peoples R China
来源：
DYES AND PIGMENTS | 2015年 / 114卷
基金：
中国国家自然科学基金;
关键词：
Fluorescent probe; 'OFF-ON'; Selective; Cysteine; Bioimaging; Senstivity; HIGHLY SELECTIVE DETECTION; CYSTEINE; HOMOCYSTEINE; THIOLS; SENSOR; CHEMOSENSOR; QUANTIFICATION; NANOPARTICLES; FLUOROGENS; SQUARAINE;
D O I：
10.1016/j.dyepig.2014.11.004
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Up to date, the design of highly selective probes for Cys, Hcy, and GSH is still a challenge and very few examples have been reported so far. In this work, the compound, N-[4-Methylcoumarin-7-yl] maleimide was synthesized and it can specially recognize on Cys as an 'OFF ON' fluorescent probe. For specific recognition on Cys of probe depends on its maleimide group, the structural and acidic differences of biothiol itself. Furthermore, the ability of probe to detect Cys in living cells (HepG2 cells) via an enhancement of the fluorescence was proved. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：105 / 109
页数：5
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