Asymmetric synthesis of both the enantiomers of antidepressant venlafaxine and its analogues

被引：12

作者：

Bhuniya, Rajib ^{[1
]}

Nanda, Samik ^{[1
]}

机构：

[1] IIT Kharagpur, Dept Chem, Kharagpur 721302, W Bengal, India

来源：

TETRAHEDRON LETTERS | 2012年 / 53卷 / 15期

关键词：

Antidepressants; Hydroxynitrile lyase; Lipase catalyzed kinetic resolution; Asymmetric synthesis; LYASE-CATALYZED ADDITION; 4-SUBSTITUTED CYCLOHEXANONES; CYANOHYDRINS; DERIVATIVES; ALCOHOLS; HCN;

D O I：

10.1016/j.tetlet.2012.02.025

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chemoenzymatic asymmetric synthesis of antidepressant agent venlafaxine and its analogue have been reported in this communication. The main highlight of the reported synthesis is the stereoselective synthesis of cyanohydrins by (S)-hydroxynitrile lyase (Hevea brasiliensis) followed by lipase catalyzed kinetic resolution. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1990 / 1992

页数：3

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