New bioactive bromotyrosine-derived alkaloid from a marine sponge Aplysinella sp.

被引：11

作者：

Ankudey, Frank Joy ^{[2
]}

Kiprof, Paul ^{[2
]}

Stromquist, Emily R. ^{[2
]}

Chang, Leng Chee ^{[1
,2
]}

机构：

[1] Univ Hawaii, Coll Pharm, Dept Pharmaceut Sci, Hilo, HI 96720 USA

[2] Univ Minnesota, Dept Chem & Biochem, Duluth, MN 55812 USA

来源：

PLANTA MEDICA | 2008年 / 74卷 / 05期

关键词：

bromotyrosine alkaloids; protein phosphorylation inhibitors; marine sponge; Aplysinella sp; hyphae formation inhibition;

D O I：

10.1055/s-2008-1074506

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new bromotyrosine-derived alkaloid, (+)-aply-sinillin (1), together with seven known compounds, was isolated from the crude organic extract of the marine sponge Aplysinella sp. collected from the Federated States of Micronesia. The structure of 1 was deduced by NMR and mass spectral techniques. Compounds 1-8 were evaluated for their inhibitory activity with the hyphae formation inhibition assay in Streptomyces 85E. Compounds 1 and 8 exhibited antiproliferative activities against the human breast adenocarcinoma cancer cell line MCF-7.

引用

页码：555 / 559

页数：5

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