New bioactive bromotyrosine-derived alkaloid from a marine sponge Aplysinella sp.

被引：11
|
作者：
Ankudey, Frank Joy [2 ]
Kiprof, Paul [2 ]
Stromquist, Emily R. [2 ]
Chang, Leng Chee [1 ,2 ]
机构：
[1] Univ Hawaii, Coll Pharm, Dept Pharmaceut Sci, Hilo, HI 96720 USA
[2] Univ Minnesota, Dept Chem & Biochem, Duluth, MN 55812 USA
来源：
PLANTA MEDICA | 2008年 / 74卷 / 05期
关键词：
bromotyrosine alkaloids; protein phosphorylation inhibitors; marine sponge; Aplysinella sp; hyphae formation inhibition;
D O I：
10.1055/s-2008-1074506
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A new bromotyrosine-derived alkaloid, (+)-aply-sinillin (1), together with seven known compounds, was isolated from the crude organic extract of the marine sponge Aplysinella sp. collected from the Federated States of Micronesia. The structure of 1 was deduced by NMR and mass spectral techniques. Compounds 1-8 were evaluated for their inhibitory activity with the hyphae formation inhibition assay in Streptomyces 85E. Compounds 1 and 8 exhibited antiproliferative activities against the human breast adenocarcinoma cancer cell line MCF-7.
引用
收藏
页码：555 / 559
页数：5
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