Influenza virus resistance to neuraminidase inhibitors

被引：37
|
作者：
Mendel, DB
Sidwell, RW
机构：
[1] Gilead Sci Inc, Foster City, CA 94404 USA
[2] Utah State Univ, Inst Antiviral Res, Logan, UT USA
来源：
DRUG RESISTANCE UPDATES | 1998年 / 1卷 / 03期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/S1368-7646(98)80038-1
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The recent reports from Hong Kong of an avian influenza virus which caused the death of six people has served to remind us of the constant threat of pandemics posed by influenza. Recently, structure-based drug design has resulted in the discovery of a new class of antiviral agents which specifically target the influenza virus neuraminidase. Two neuraminidase inhibitors are currently undergoing clinical evaluation for the prevention and treatment of influenza virus infection in man. Here we review the results of in vitro and in vivo studies relating to the potential development of resistance to this new class of compounds.
引用
收藏
页码：184 / 189
页数：6
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