Nickel-Catalyzed Three-Component Domino Reactions of Aryl Grignard Reagents, Alkynes, and Aryl Halides Producing Tetrasubstituted Alkenes

被引：112

作者：

Xue, Fei ^{[1
]}

Zhao, Jin ^{[1
]}

Hor, T. S. Andy ^{[1
,2
]}

Hayashi, Tamio ^{[1
,2
]}

机构：

[1] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore

[2] Agcy Sci Technol & Res, Inst Mat Res & Engn, Singapore 117602, Singapore

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2015年 / 137卷 / 09期

关键词：

CROSS-COUPLING REACTION; CARBON BOND FORMATION; INTERNAL ALKYNES; STEREOSELECTIVE-SYNTHESIS; IODIDES; CARBOMETALATION; ARYLMAGNESIATION; CARBOPALLADATION; ORGANOMAGNESIUM; OLEFINS;

D O I：

10.1021/ja513166w

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Three-component reaction of aryl Grignard reagerits, alkynes, and aryl halides in the presence of 1 mol % of NiCl2 proceeded sequentially through carbomagnesiation of the alkyne followed by cross-coupling of the resulting alkenyl Grignard reagent with aryl halide to give tetrasubstituted alkene in high yields.

引用

页码：3189 / 3192

页数：4

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