Discovery of Ecallantide: A potent and selective inhibitor of plasma kallikrein

被引：3
|
作者：
Ladner, R. [1 ]
Kent, R. [1 ]
Ley, A. [1 ]
Nixon, A. [1 ]
Sexton, D. [1 ]
机构：
[1] Dyax Corp, Cambridge, MA USA
来源：
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2007年 / 119卷 / 01期
关键词：
D O I：
10.1016/j.jaci.2006.12.591
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
1218
引用
收藏
页码：S312 / S312
页数：1
相关论文
共 50 条
  • [41] Discovery of highly potent small molecule kallikrein inhibitors
    Zhang, J.
    Kirshnan, R.
    Arnold, C. S.
    Mattsson, E.
    Kilpatrick, J. M.
    Bantia, S.
    Dehghani, A.
    Boudreaux, B.
    Gupta, S. N.
    Kotian, P. L.
    Chand, P.
    Babu, Y. S.
    MOLECULAR IMMUNOLOGY, 2007, 44 (1-3) : 263 - 263
  • [42] Discovery of OICR-10268: A potent and selective BCL6 inhibitor
    Watson, Lain D.
    Isaac, Methvin
    Wilson, Brian
    Anh Chau
    Morin, Justin
    Subramanian, Pandiaraju
    Mamai, Ahmed
    Joseph, Babu
    Prakesch, Michael
    Uehling, David
    Abibi, Ayome
    Marcellus, Richard
    Strathdee, Craig
    Subramaniam, Ratheesh
    Theriault, Brigitte
    Winston, Jeffrey
    Chan, Manuel
    Griffin, Carly
    Cheung, Herman
    Kiyota, Taira
    Undzys, Elijus
    Aman, Ahmed
    Poda, Gennady
    Kuntz, Doug
    Pomroy, Neil C.
    Prive, Gil G.
    Al-awar, Rima
    CANCER RESEARCH, 2019, 79 (13)
  • [43] Discovery of a Potent and Selective DDR1 Receptor Tyrosine Kinase Inhibitor
    Kim, Hyung-Gu
    Tan, Li
    Weisberg, Ellen L.
    Liu, Feiyang
    Canning, Peter
    Choi, Hwan Geun
    Ezell, Scott A.
    Wu, Hong
    Zhao, Zheng
    Wang, Jinhua
    Mandinova, Anna
    Griffin, James D.
    Bullock, Alex N.
    Liu, Qingsong
    Lee, Sam W.
    Gray, Nathanael S.
    ACS CHEMICAL BIOLOGY, 2013, 8 (10) : 2145 - 2150
  • [44] Discovery and Biological Profiling of Potent and Selective mTOR Inhibitor GDC-0349
    Pei, Zhonghua
    Blackwood, Elizabeth
    Liu, Lichuan
    Malek, Shiva
    Belvin, Marcia
    Koehler, Michael F. T.
    Ortwine, Daniel F.
    Chen, Huifen
    Cohen, Frederick
    Kenny, Jane R.
    Bergeron, Philippe
    Lau, Kevin
    Ly, Cuong
    Zhao, Xianrui
    Estrada, Anthony A.
    Tom Truong
    Epler, Jennifer A.
    Nonomiya, Jim
    Lan Trinh
    Sideris, Steve
    Lesnick, John
    Bao, Linda
    Vijapurkar, Ulka
    Mukadam, Sophie
    Tay, Suzanne
    Deshmukh, Gauri
    Chen, Yung-Hsiang
    Ding, Xiao
    Friedman, Lori S.
    Lyssikatos, Joseph P.
    ACS MEDICINAL CHEMISTRY LETTERS, 2013, 4 (01): : 103 - 107
  • [45] Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR
    Petros, Andrew M.
    Huth, Jeffrey R.
    Oost, Thorsten
    Park, Cheol-Min
    Ding, Hong
    Wang, Xilu
    Zhang, Haichao
    Nimmer, Paul
    Mendoza, Renaldo
    Sun, Chaohong
    Mack, Jamey
    Walter, Karl
    Dorwin, Sarah
    Gramling, Emily
    Ladror, Uri
    Rosenberg, Saul H.
    Elmore, Steven W.
    Fesik, Stephen W.
    Hajduk, Philip J.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (22) : 6587 - 6591
  • [46] Discovery of DS-1971a, a Potent, Selective NaV1.7 Inhibitor
    Shinozuka, Tsuyoshi
    Kobayashi, Hiroyuki
    Suzuki, Sayaka
    Tanaka, Kyosuke
    Karanjule, Narayan
    Hayashi, Noriyuki
    Tsuda, Toshifumi
    Tokumaru, Eri
    Inoue, Masahiro
    Ueda, Kiyono
    Kimoto, Hiroko
    Domon, Yuki
    Takahashi, Sakiko
    Kubota, Kazufumi
    Yokoyama, Tomihisa
    Shimizugawa, Akiko
    Koishi, Ryuta
    Fujiwara, Chie
    Asano, Daigo
    Sakakura, Tomoko
    Takasuna, Kiyoshi
    Abe, Yasuyuki
    Watanabe, Toshiyuki
    Kitano, Yutaka
    JOURNAL OF MEDICINAL CHEMISTRY, 2020, 63 (18) : 10204 - 10220
  • [47] Discovery of PF-07220060, a potent and selective CDK4 inhibitor
    Anders, Lars
    Gallego, Gary
    CANCER RESEARCH, 2024, 84 (07)
  • [48] Discovery of AS2521780, a novel, potent, selective PKCq inhibitor as an immunosuppressive agent
    Tanaka, Akira
    Mukoyoshi, Koichiro
    Kunikawa, Shigeki
    Takasuna, Yuji
    Nagashima, Shinya
    Chida, Noboru
    Ohkubo, Mitsuru
    Ohta, Mitsuaki
    Takeuchi, Makoto
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 245
  • [49] Discovery of a potent and selective c-Kit inhibitor for the treatment of inflammatory diseases
    Chen, Ning
    Burli, Roland W.
    Neira, Susana
    Hungate, Randall
    Zhang, Dawei
    Yu, Violeta
    Nguyen, Yen
    Tudor, Yanyan
    Plant, Matthew
    Flynn, Shaun
    Meagher, Kristin L.
    Lee, Matthew R.
    Zhang, Xuxia
    Itano, Andrea
    Schrag, Michael
    Xu, Yang
    Ng, Gordon Y.
    Hu, Essa
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (14) : 4137 - 4141
  • [50] Discovery of Potent Selective Nonzinc Binding Autotaxin Inhibitor BIO-32546
    Ma, Bin
    Zhang, Lei
    Sun, Lihong
    Xin, Zhili
    Kumaravel, Gnanasambandam
    Marcotte, Douglas
    Chodaparambil, Jayanth, V
    Wang, Qin
    Wehr, Angela
    Jing, Jing
    Hong, Victor Sukbong
    Wang, Ti
    Huang, Carol
    Shao, Zhaohui
    Mi, Sha
    ACS MEDICINAL CHEMISTRY LETTERS, 2021, 12 (07): : 1124 - 1129
12345