Assessments Hematology of De-adaptation to High Altitude Tibetans in Tibet

Objective: Tibet Tibetan living in the plateau low oxygen environment for a long time, the body structure and physiological and biochemical levels on the plateau low oxygen to produce a series of adaptive mechanisms. This article through to growth at different altitudes, different gender, age and ethnic characteristics of hematology study, discusses the characteristics of the Tibetan plateau adaptation hematology, at the same time, the growth of different altitude in Tibet Tibetan students, all came to shaanxi xianyang Tibet institute for nationalities on the mainland to go to school, away from the plateau environment, the body will appear plateau to adapt to a series of change, to study the changes in the hematology, explore the Tibetan plateau to adapt to the characteristics of hematology. Methods: the growth in average altitude of 3650 m, 3813 m and 4525 m and 5200 m of 2500 (aged 17 to 29) healthy Tibetan and han Chinese in hematology characteristics of plain and plateau, determination of red blood cell volume, erythrocyte morphology, the determination of hemoglobin content and EPO levels in the blood. Results: Both Tibetan and han ethnic group, at the same altitude men on the number of red blood cells, hemoglobin content and blood EPO levels than with the elevation of women (P < 0. 05). But whether men or women, Tibetan number of red blood cells in the blood, hemoglobin content and blood EPO content was significantly lower than with the elevation of the han ethnic group (P < 0.05). With the increase of altitude, the han nationality male hemoglobin content and erythrocyte number and the EPO levels rise from han women, but in the Tibetan population in such a trend is not obvious (P > 0.05). At high altitudes, as the growth of the age, both the Tibetan and han ethnic group, the number of red blood cells, hemoglobin content and the content of blood EPO has obvious rising trend, but the rising trend of the han nationality was obviously higher than that of Tibetan rising trend (P < 0.05). Changes in the structure of han Chinese male and female red blood cells are significantly higher than Tibetan (P > 0.05). Plateau to adapt to the indigenous Tibetan RBC, HGB, HCT appear is reduced, and the control group no significant difference (P > 0.05), with the return from the plains of prolonged, the various values gradually close to the control group. Conclusion: Tibet plateau adaptation than moved to the han, Tibetan in the number of red blood cells and hemoglobin content and the content of blood EPO is superior to the han nationality and more able to adapt to the plateau low oxygen environment. Tibetan can be adapted to the plateau, affected by many factors, in terms of hematology, gender, age and the altitude on the people living in high altitude of hematology characteristics have important influence. Tibet plateau adaptation off Tibetan plateau short-term exposure after returning from the plains, in plateau adaptation of hematology indexes off a slower recovery. Tibet, frequent short time between Tibet and inland large influence on hematology indices abnormal. Further serum proteomics is still in research.