Risk of Obstructive Sleep Apnea and Echocardiographic Parameters

被引:3
|
作者
Leite, Adson Renato [1 ]
Martinez, Diana Maria [1 ]
Garcia-Rosa, Maria Luiza [1 ]
Macedo, Erica de Abreu [1 ]
Lagoeiro, Antonio Jose [1 ]
Martins, Wolney de Andrade [1 ]
Vasques-Netto, Delvo [1 ]
dos Santos, Carita Cunha [1 ]
机构
[1] Univ Fed Fluminense, Med Clin, Niteroi, RJ, Brazil
关键词
Cardiovascular Diseases; Sleep Apnea; Obstruction; Indicators; Morbimortality; Heart Failure; Ecocardiography/methods; Polysonography/methods; LEFT-VENTRICULAR FUNCTION; CARDIOVASCULAR-DISEASE; BERLIN QUESTIONNAIRE; HEART-FAILURE; IMPACT; DYSFUNCTION;
D O I
10.5935/abc.20190181
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Obstructive sleep apnea (OSA) is a chronic progressive disorder with high mortality and morbidity rate, associated with cardiovascular diseases (CVD), especially heart failure (HF). The pathophysiological changes related to OSA can directly affect the diastolic function of the left ventricle. Objectives: To assess the association of the risk of OSA, evaluated by the Berlin Questionnaire (BQ), and echocardiographic (ECHO) parameters related to diastolic dysfunction in individuals without HF assisted in primary care. Methods: A cross-sectional study that included 354 individuals (51% women) aged 45 years or older. All individuals selected were submitted to an evaluation that included the following procedures: consultation, filling out the BQ, clinical examination, laboratory examination and transthoracic Doppler echocardiography (TDE). Continuous data are presented as medians and interquartile intervals, and categoric variables in absolute and relative frequencies. The variables associated with risk of OSA and at the 0.05 level integrated the gamma regression models with a log link function. A value of p < 0.05 was considered an indicator of statistical significance. Exclusion criteria were presence of HF, to fill out the BQ and patients with hypertension and obesity not classified as high risk for OSA by other criteria. All individuals were evaluated on a single day with the following procedures: medical appointment, BQ, laboratory tests and ECHO. Results: Of the 354 individuals assessed, 63% were classified as having high risk for OSA. The patients with high risk for OSA present significantly abnormal diastolic function parameters. High risk for OSA confirmed positive and statistically significant association, after adjustments, with indicators of diastolic function, such as indexed left atrium volume LAV-i (p = 0.02); E'/A' (p < 0.01), A (p = 0.02), E/A (p < 0.01). Conclusion: Our data show that patients at high risk for OSA present worsened diastolic function parameters measured by TDE.
引用
收藏
页码:1084 / 1089
页数:6
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