Synthesis and biological evaluation of new jasplakinolide (jaspamide) analogs

被引：13

作者：

Ghosh, Arun K. ^{[1
,2
]}

Dawson, Zachary L. ^{[1
,2
]}

Moon, Deuk Kyu ^{[1
,2
]}

Bai, Ruoli ^{[3
]}

Hamel, Ernest ^{[3
]}

机构：

[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

[2] Purdue Univ, Dept Med Chem, W Lafayette, IN 47907 USA

[3] NCI, Screening Technol Branch, Dev Therapeut Program, Div Canc Treatment & Diag,NIH, Frederick, MD 21702 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 17期

基金：

美国国家卫生研究院;

关键词：

Jasplakinolide; Actin filament; Natural product; Synthesis; Antitumor activity; ENANTIOSELECTIVE TOTAL-SYNTHESIS; MARINE SPONGE; ACTIN POLYMERIZATION; CYCLODEPSIPEPTIDE; PHALLOIDIN; CELLS;

D O I：

10.1016/j.bmcl.2010.07.023

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Synthesis and biological evaluation of jasplakinolide analogs are described. The synthesis of analogs utilized a diastereoselective syn-aldol reaction and an orthoester Claisen rearrangement as key steps. All synthetic analogs were evaluated for their ability to disrupt the actin cytoskeleton. Compounds 2, 3, and 4 essentially displayed similar activity to jasplakinolide. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：5104 / 5107

页数：4

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