Single photon imaging at ultra-high resolution

被引:15
|
作者
Bellazzini, R. [1 ]
Spandre, G. [1 ]
Minuti, M. [1 ]
Brez, A. [1 ]
Baldini, L. [1 ]
Latronico, L. [1 ]
Omodei, N. [1 ]
Sgro, C. [1 ]
Bregeon, J. [1 ]
Razzano, M. [1 ]
Pinchera, M. [1 ]
Tremsin, A. [2 ]
McPhate, J. [2 ]
Vallerga, J. V. [2 ]
Siegmund, O. [2 ]
机构
[1] Ist Nazl Fis Nucl, Sez Pisa, Pisa, Italy
[2] SSL, Berkeley, CA USA
关键词
photon counting; high spatial resolution; coincidence detection;
D O I
10.1016/j.nima.2008.03.040
中图分类号
TH7 [仪器、仪表];
学科分类号
0804 ; 080401 ; 081102 ;
摘要
We present a detection system capable of imaging both single photon/positive ion and multiple coincidence photons/positive ions with extremely high spatial resolution. In this detector the photoelectrons excited by the incoming photons are multiplied by microchannel plate(s) (MCP). The process of multiplication is spatially constrained within an MCP pore, which can be as small as 4 mu m for commercially available MCPs. An electron cloud originated by a single photoelectron is then encoded by a pixellated custom analog ASIC consisting of 105 K charge sensitive pixels of 50 mu m in size arranged on a hexagonal grid. Each pixel registers the charge with an accuracy of < 100 electrons rms. Computation of the event centroid from the readout charges results in an accurate event position. A large number of simultaneous photons spatially separated by similar to 0.4 mm can be detected simultaneously allowing multiple coincidence operation for the experiments where a large number of incoming photons/positive ions have to be detected simultaneously. The experimental results prove that the spatial resolution of the readout system itself is similar to 3 mu m FWHM enabling detection resolution better than 6 1 pm for the small pore MCPs. An attractive feature of the detection system is its capability to register the timing of each incoming photon/positive ion (in single photon detection mode) or of the first incoming particle (for the multiple coincidence detection) with an accuracy of similar to 130ps FWHM. There is also virtually no dark count noise in the detection system making it suitable for low count rate applications. (c) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码:125 / 128
页数:4
相关论文
共 50 条
  • [31] Ultra-high resolution imaging of thin films and single strands of polythiophene using atomic force microscopy
    Korolkov, Vladimir V.
    Summerfield, Alex
    Murphy, Alanna
    Amabilino, David B.
    Watanabe, Kenji
    Taniguchi, Takashi
    Beton, Peter H.
    NATURE COMMUNICATIONS, 2019, 10 (1)
  • [32] Ultra-high resolution imaging of thin films and single strands of polythiophene using atomic force microscopy
    Vladimir V. Korolkov
    Alex Summerfield
    Alanna Murphy
    David B. Amabilino
    Kenji Watanabe
    Takashi Taniguchi
    Peter H. Beton
    Nature Communications, 10
  • [33] Ultra-High Resolution Imaging of Cornea In Non-Human Primates
    Barathi, Veluchamy A.
    Devarajan, Kavya
    Tan, Bingyao
    Chua, Jacqueline
    Werkmeister, Rene M.
    Schmetterer, Leopold
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2019, 60 (09)
  • [34] Ultra-High Resolution 3D Imaging of Whole Cells
    Huang, Fang
    Sirinakis, George
    Allgeyer, Edward S.
    Schroeder, Lena K.
    Duim, Whitney C.
    Kromann, Emil B.
    Phan, Thomy
    Rivera-Molina, Felix E.
    Myers, Jordan R.
    Irnov, Irnov
    Lessard, Mark
    Zhang, Yongdeng
    Handel, Mary Ann
    Jacobs-Wagner, Christine
    Lusk, C. Patrick
    Rothman, James E.
    Toomre, Derek
    Booth, Martin J.
    Bewersdorf, Joerg
    CELL, 2016, 166 (04) : 1028 - 1040
  • [35] Ultra-high resolution three dimensional imaging throughout whole cells
    Huang, Fang
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 252
  • [36] ULTRA-HIGH RESOLUTION SUSCEPTIBILITY WEIGHTED IMAGING OF TRAUMATIC BRAIN INJURY
    Ravi, Harshan
    Wang, Wen-Tung
    Dzung Pham
    Butman, John
    JOURNAL OF NEUROTRAUMA, 2018, 35 (16) : A151 - A152
  • [37] Ultra-high resolution CT imaging of interstitial lung disease: impact of photon-counting CT in 112 patients
    Yann Gaillandre
    Alain Duhamel
    Thomas Flohr
    Jean-Baptiste Faivre
    Suonita Khung
    Antoine Hutt
    Paul Felloni
    Jacques Remy
    Martine Remy-Jardin
    European Radiology, 2023, 33 : 5528 - 5539
  • [38] Low Dose Ultra-High Resolution Sinus Imaging Using Photon-Counting Detector CT with Tin Filter
    Rajendran, K.
    Zhou, W.
    Tao, S.
    Voss, B.
    Bruesewitz, M.
    Weaver, J.
    DeLone, D.
    Fletcher, J.
    McCollough, C.
    Leng, S.
    MEDICAL PHYSICS, 2019, 46 (06) : E409 - E409
  • [39] Ultra-high resolution CT imaging of interstitial lung disease: impact of photon-counting CT in 112 patients
    Gaillandre, Yann
    Duhamel, Alain
    Flohr, Thomas
    Faivre, Jean-Baptiste
    Khung, Suonita
    Hutt, Antoine
    Felloni, Paul
    Remy, Jacques
    Remy-Jardin, Martine
    EUROPEAN RADIOLOGY, 2023, 33 (08) : 5528 - 5539
  • [40] Ultra-high sensitivity multi-photon detection imaging in proteomics analyses
    Kleiner, O
    Price, DA
    Ossetrova, N
    Osetrov, S
    Volkovitsky, P
    Drukier, AK
    Godovac-Zimmermann, J
    PROTEOMICS, 2005, 5 (09) : 2322 - 2330