LANDMARK ANALYSES IN THE PIVOTAL PONATINIB PACE TRIAL: IMPACT OF EARLY RESPONSES ON 3-YEAR OUTCOMES IN HEAVILY PRETREATED CP-CML PATIENTS

被引：0

作者：

Mueller, M. ^{[1
]}

Baccarani, M. ^{[2
]}

Deininger, M. W. ^{[3
]}

Guilhot, F. ^{[4
]}

Hochhaus, A. ^{[5
]}

Hughes, T. P. ^{[6
,7
]}

Shah, N. P. ^{[8
]}

Talpaz, M. ^{[9
]}

Lustgarten, S. ^{[10
]}

Rivera, V. M. ^{[10
]}

Clackson, T. ^{[10
]}

Haluska, F. G. ^{[10
]}

Cortes, J. E. ^{[11
]}

机构：

[1] Univ Med Mannheim, Mannheim, Germany

[2] S Orsola Malpighi Univ Hosp, Bologna, Italy

[3] Univ Utah, Huntsman Canc Inst, Salt Lake City, UT USA

[4] CHU Poitiers, Inserm CIC 1402, Poitiers, France

[5] Jena Univ Hosp, Jena, Germany

[6] South Australian Hlth & Med Res Inst, Adelaide, SA, Australia

[7] Univ Adelaide, Adelaide, SA, Australia

[8] Univ Calif San Francisco, San Francisco, CA 94143 USA

[9] Univ Michigan, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

[10] ARIAD Pharmaceut Inc, Cambridge, MA USA

[11] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

来源：

HAEMATOLOGICA | 2016年 / 101卷

关键词：

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

P615

引用

页码：239 / 239

页数：1

共 43 条

[11] Ponatinib In Heavily Pretreated Patients With Chronic Phase Chronic Myeloid Leukemia (CP-CML): Management Of Adverse Events (AEs)
Le Coutre, Philipp D.
Kim, Dong-Wook
Pinilla-Ibarz, Javier
Paquette, Ronald
Chuah, Charles
Nicolini, Franck E.
Apperley, Jane F.
Khoury, H. Jean
Talpaz, Moshe
Dipersio, John F.
DeAngelo, Daniel J.
Abruzzese, Elisabetta
Rea, Delphine
Baccarani, Michele
Muller, Martin C.
Gambacorti-Passerini, Carlo
Lustgarten, Stephanie
Yanase, Kumiko
Turner, Christopher D.
Haluska, Frank G.
Guilhot, Francois
Deininger, Michael W.
Hochhaus, Andreas
Hughes, Timothy P.
Goldman, John M.
Shah, Neil P.
Kantarjian, Hagop M.
Cortes, Jorge E.
BLOOD, 2013, 122 (21)
[12] High-Resolution Analysis of the Relationship Between Ponatinib Dose and Molecular Response in CP-CML Patients in the PACE Trial
Pritchard, Justin R.
Lustgarten, Stephanie
Hodgson, Graeme
Baccarani, Michele
Cortes, Jorge E.
Deininger, Michael W.
Guilhot, Francois
Hochhaus, Andreas
Hughes, Timothy P.
Shah, Neil P.
Talpaz, Moshe
Clackson, Tim
Haluska, Frank G.
Knickerbocker, Ronald
Rivera, Victor M.
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2015, 15 : S212 - S212
[13] Ponatinib efficacy and safety in heavily pretreated leukemia patients (Pts) in the PACE trial at 3 years
le Coutre, P. D.
Cortes, J. E.
Kim, D. -W
Pinilla-Ibarz, J.
Paquette, R.
Chuah, C.
Nicolini, F. E.
Apperley, J. F.
Khoury, H. J.
Talpaz, M.
DeAngelo, D. J.
Abruzzese, E.
Rea, D.
Baccarani, M.
Mueller, M. C.
Gambacorti-Passerini, C.
Lustgarten, S.
Rivera, V. M.
Clackson, T.
Haluska, F. G.
Guilhot, F.
Deininger, M. W.
Hochhaus, A.
Hughes, T. P.
Shah, N. P.
Kantarjian, H. M.
ONCOLOGY RESEARCH AND TREATMENT, 2015, 38 : 182 - 183
[14] Efficacy and Safety Of Ponatinib Following Failure Of Nilotinib In Patients With Chronic Phase Chronic Myeloid Leukemia (CP-CML) In The PACE Trial
Kantarjian, Hagop M.
Cortes, Jorge E.
Kim, Dong-Wook
Pinilla-Ibarz, Javier
le Coutre, Philipp D.
Paquette, Ronald
Chuah, Charles
Nicolini, Franck E.
Apperley, Jane F.
Khoury, H. Jean
Talpaz, Moshe
DiPersio, John F.
DeAngelo, Daniel J.
Abruzzese, Elisabetta
Rea, Delphine
Baccarani, Michele
Mueller, Martin C.
Gambacorti-Passerini, Carlo
Lustgarten, Stephanie
Rivera, Victor M.
Clackson, Tim
Turner, Christopher D.
Haluska, Frank G.
Guilhot, Francois
Deininger, Michael W.
Hochhaus, Andreas
Hughes, Timothy P.
Goldman, John M.
Shah, Neil P.
BLOOD, 2013, 122 (21)
[15] 5-Year Updates from the Pivotal Phase 2 Ponatinib PACE Trial: Efficacy, Safety and Landmark Analysis in Heavily Pretreated Patients with Chronic-Phase Chronic Myeloid Leukemia
Cortes, Jorge E.
Kantarjian, Hagop M.
Pinilla-Ibarz, Javier
le Coutre, Philipp D.
Paquette, Ronald
Chuah, Charles
Nicolini, Franck E.
Talpaz, Moshe
Baccarani, Michele
Deininger, Michael W.
Hochhaus, Andreas
Hughes, Timothy P.
Shah, Neil P.
Lustgarten, Stephanie
Santillana, Sergio
Rivera, Victor M.
Clackson, Tim
Mueller, Martin C.
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2017, 17 : S307 - S308
[16] Arterial Occlusive Events (AOEs) in the Phase 2 Ponatinib PACE Trial: 5-Year Update in Heavily Treated Patients (Pts) with Chronic-Phase Chronic Myeloid Leukemia (CP-CML)
Cortes, Jorge E.
Nicolini, Franck Emmanuel
Hochhaus, Andreas
le Coutre, Philipp D.
Kim, Dong-Wook
Pinilla-Ibarz, Javier
Paquette, Ronald
Chuah, Charles
Apperley, Jane F.
Talpaz, Moshe
DeAngelo, Daniel J.
Abruzzese, Elisabetta
Rea, Delphine
Mueller, Martin C.
Gambacorti-Passerini, Carlo
Castagnetti, Fausto
Lustgarten, Stephanie
Neumann, Frank
Clackson, Timothy P.
Guilhot, Francois
Deininger, Michael W.
Hughes, Timothy P.
Shah, Neil P.
Kantarjian, Hagop M.
BLOOD, 2017, 130
[17] Efficacy and Safety Of Ponatinib Following Failure Of Dasatinib In Patients (pts) With Chronic Phase Chronic Myeloid Leukemia (CP-CML) In The PACE Trial
Hochhaus, Andreas
Cortes, Jorge E.
Kim, Dong-Wook
Pinilla-Ibarz, Javier
le Coutre, Philipp D.
Paquette, Ronald
Chuah, Charles
Nicolini, Franck E.
Apperley, Jane F.
Khoury, H. Jean
Talpaz, Moshe
DiPersio, John F.
DeAngelo, Daniel J.
Abruzzese, Elisabetta
Rea, Delphine
Baccarani, Michele
Mueller, Martin C.
Gambacorti-Passerini, Carlo
Lustgarten, Stephanie
Rivera, Victor M.
Clackson, Tim
Turner, Christopher D.
Haluska, Frank G.
Deininger, Michael W.
Hughes, Timothy P.
Goldman, John M.
Shah, Neil P.
Kantarjian, Hagop M.
Guilhot, Francois
BLOOD, 2013, 122 (21)
[18] LONG-TERM EFFICACY AND SAFETY OF PONATINIB IN HEAVILY PRETREATED LEUKEMIA PATIENTS: 4-YEAR RESULTS FROM THE PIVOTAL PHASE 2 PACE TRIAL
Cortes, J. E.
Pinilla-Ibarz, J.
le Coutre, P. D.
Paquette, R.
Chuah, C.
Nicolini, F. E.
Apperley, J. F.
Khoury, H. J.
Talpaz, M.
Baccarani, M.
Lustgarten, S.
Haluska, F. G.
Guilhot, F.
Deininger, M. W.
Hochhaus, A.
Hughes, T. P.
Shah, N. P.
Kantarjian, H. M.
HAEMATOLOGICA, 2016, 101 : 60 - 61
[19] 4-year results of the ponatinib phase II PACE trial in patients (pts) with heavily pretreated leukemia.
Cortes, Jorge E.
Pinilla-Ibarz, Javier
Le Coutre, Philipp D.
Paquette, Ronald
Chuah, Charles
Nicolini, Franck E.
Apperley, Jane
Khoury, Hanna Jean
Talpaz, Moshe
Baccarani, Michele
Lustgarten, Stephanie
Haluska, Frank G.
Guilhot, Francois
Deininger, Michael W. N.
Hochhaus, Andreas
Hughes, Timothy P.
Shah, Neil P.
Kantarjian, Hagop M.
JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (15)
[20] Efficacy and Safety of Ponatinib in CP-CML Patients By Number of Prior Tyrosine Kinase Inhibitors: 4-Year Follow-up of the Phase 2 PACE Trial
Hochhaus, Andreas
Cortes, Jorge E.
Kim, Dong-Wook
Pinilla-Ibarz, Javier
le Coutre, Philipp D.
Paquette, Ronald
Chuah, Charles
Nicolini, Franck. E.
Apperley, Jane F.
Khoury, H. Jean
Talpaz, Moshe
DeAngelo, Daniel J.
Abruzzese, Elisabetta
Rea, Delphine
Baccarani, Michele
Muller, Martin C.
Gambacorti-Passerini, Carlo
Lustgarten, Stephanie
Conlan, Maureen
Rivera, Victor M.
Guilhot, Francois
Deininger, Mochael W.
Hughes, Timothy P.
Shah, Neil P.
Kantarjian, Hagop M.
BLOOD, 2015, 126 (23)

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